Translating Developmental Principles to Generate Human Gastric Organoids

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Eicher, Alexandra K.; Berns, H. Matthew; Wells, James M.;
  • Publisher: Elsevier
  • Journal: Cellular and Molecular Gastroenterology and Hepatology, volume 5, issue 3, pages 353-363 (issn: 2352-345X, eissn: 2352-345X)
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  • Identifiers: pmc: PMC5852324, doi: 10.1016/j.jcmgh.2017.12.014
  • Subject: Diseases of the digestive system. Gastroenterology | Directed Differentiation | Endoderm | PSC, pluripotent stem cell | Pluripotent Stem Cells | Organoids | GI, gastrointestinal | BMP, bone morphogenetic protein | Gastric Development | hPSC, human pluripotent stem cell | Shh, Sonic hedgehog | ENS, enteric nervous system | HGO, human gastric organoid | RC799-869 | Review | e, embryonic day | 3-D, 3-dimensional | ENCC, enteric neural crest cell | HDGC, hereditary diffuse gastric cancer | ECL, enterochromaffin-like
    mesheuropmc: digestive, oral, and skin physiology

Gastric diseases, including peptic ulcer disease and gastric cancer, are highly prevalent in human beings. Despite this, the cellular biology of the stomach remains poorly understood relative to other gastrointestinal organs such as the liver, intestine, and colon. In p... View more