publication . Article . Other literature type . 2012

Btg1 is required to maintain the pool of stem and progenitor cells of the dentate gyrus and subventricular zone

Farioli-Vecchioli, Stefano; Micheli, Laura; Saraulli, Daniele; Ceccarelli, Manuela; Cannas, Sara; Scardigli, Raffaella; Leonardi, Luca; Cinà, Irene; Costanzi, Marco; Ciotti, Maria Teresa; ...
Open Access English
  • Published: 01 Aug 2012
  • Publisher: HAL CCSD
Abstract
Btg1 belongs to a family of cell cycle inhibitory genes. We observed that <em>Btg1</em> is highly expressed in adult neurogenic niches, i.e., the dentate gyrus and subventricular zone (SVZ). Thus, we generated <em>Btg1</em> knockout mice to analyze the role of <em>Btg1</em> in the process of generation of adult new neurons. Ablation of <em>Btg1</em> causes a transient increase of the proliferating dentate gyrus stem and progenitor cells at post-natal day 7; however, at 2 months of age the number of these proliferating cells, as well as of mature neurons, greatly decreases compared to wild-type controls. Remarkably, adult dentate gyrus stem and progenitor cells o...
Subjects
Medical Subject Headings: nervous system
free text keywords: BTG family, differentiation, knock out mice, learning and memory, proliferation, neural stem cells, neurogenic niches, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], Neuroscience, Original Research, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, BTG family;differentiation;knock out mice;learning and memory;neural stem cells;neurogenic niches;proliferation, General Neuroscience, Neurogenesis, Subventricular zone, medicine.anatomical_structure, medicine, Progenitor cell, Neural stem cell, Dentate gyrus, Neuroepithelial cell, Developmental psychology, Biology, Neuropoiesis, Adult stem cell
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publication . Article . Other literature type . 2012

Btg1 is required to maintain the pool of stem and progenitor cells of the dentate gyrus and subventricular zone

Farioli-Vecchioli, Stefano; Micheli, Laura; Saraulli, Daniele; Ceccarelli, Manuela; Cannas, Sara; Scardigli, Raffaella; Leonardi, Luca; Cinà, Irene; Costanzi, Marco; Ciotti, Maria Teresa; ...