publication . Article . 2018

In vitro antimalarial activity of Calophyllum bicolor and hemozoin crystals observed by Transmission Electron Microscope (TEM)

Jamilah Abbas;
Open Access English
  • Published: 01 Jan 2018 Journal: MATEC Web of Conferences (issn: 2261-236X, Copyright policy)
  • Publisher: EDP Sciences
<jats:p><jats:italic>Objective</jats:italic> : In continuation of our antimalarial candidate drug discovery program on Indonesia medicinal plants especially from stem bark of <jats:italic>Calophyllum bicolor. Metode</jats:italic> : We extracted of bioactive crude extract with hexane, acetone and methanol from stem bark of Calophyllum bicolor and evaluated their antimalarial activity by using parasite <jats:italic>Plasmodium falciparum in vitro. Results:</jats:italic> Methanol fraction showed most active and potent antimalarial activity dose dependent in <jats:italic>in vitro</jats:italic> experiments with IC<jats:sub>50</jats:sub> = 0.52 ppb, and hexane fraction...
free text keywords: Calophyllum bicolor, Plasmodium falciparum, in-vitro, TEM (Transmition Electron Mecroscope), Engineering (General). Civil engineering (General), TA1-2040, Acetone, chemistry.chemical_compound, chemistry, Nuclear chemistry, Methanol, In vitro, biology.organism_classification, biology, Hexane, Medicinal plants, Hemozoin

Journal ethnopharmacologically, 113, 289-302 (2011). Collins, W. J., Greenhouse, B., , Rosenthal, P. J, and Dorsey G. The used of genotyping in antimalarial clinical trials: a systematic review of published studies from Malaria J., 5: 122, 1-8. (2011).

Silva, J. R de A., Ramos, A de S, Machado, M., Moura, D., Neto, Z., Cavalheiro., M. M. C., Fiqueiredo, V E do., Amaral, A. C F., Lopes, D. A Review of antimalarial plants used in traditional medicine in communities in Portuguese-Speaking countries: Brazil, Mozambique, Cape Verde, GuineaBissau, Sao Tome and Principe and Anggola. Mem Inst Oswaldo Crus, Rio de Janeiro, Vol 106, 142-158, (2011).

Ojha, P. K, and Roy, K., Chemometric modeling, docking and in silico design of triazolopyrimidinebased dihydroorotate dehydrogenase, European J. of Medicinal Chemistry, 45, 4645-4556.

Duffy R., Wade Cristine. Discovery of anticancer drugs from antimalarial natural products: a Medline literature review, Feature, 1359-6446/06/s. www. Vol 17, no 17/18, September (2012).

Structural requirements of 3-carboxyl-4(1H)- quinolones as potential antimalarials from 2D and 3D QSAR analysis, J. of Molecular Graphics and Modelling. 44, 266-277. (2013).

Tames, A. P., Lantivt, D., Lim, E., Pezzuto, J. M., Chemosentizing action of cepharanthine against drug-resisitant human malaria, Plasmodium falciparum. J. of ethnopharmacoology, 98, 137-142.

Pouplin J N,Tran Hop, Tran Hung,Phan T A,Dolecek C, Farrar J, Tran T H, Caron P, Bodo B, Grellier P (2007). Antimalarial and cytotoxic activities of ethnopharma cologically selected medicinal plants from South Vietnam. .J. of Ethnopharma cology 109,p 417-427. (2010) [OpenAIRE]

8. Sahal D.,Kannan and Chauhan, V.SApplying malaria parasite's heme detoxification system for screening potential antimalarial drugs. Analytical Biochemisy. 312, 258-260 (2003). [OpenAIRE]

9. Ignatushchenko, M. V.. Winter, R.W., Bachinger, H. P., Hinrichs, D.V and Riscoe, M.K Xanthones as antimalarial agents : studies of a possible mode of action, FEBS letter 409, 67-73. (1997). [OpenAIRE]

10. Geral, N., Mahajan B., and Kumar S., Mitosis in the Human malaria parasite Plasmodium falciparum, Eukaryotic Cell, Vol 10, no4, 474-481 (2011)

11. Brian. J, Ford C, J, Bradbury S, Transmission electron microscope (TEM).

12. A. Jamilah. M, Hanafi, M., Artanti. N., Asih.P,B,A., and Syafruddin D, Antiplasmodial activity of hexane extract of Calophyllum Lowii. . J. of Tropical Medicinal Plants Vol 16 (Jan-Dec 2016)

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publication . Article . 2018

In vitro antimalarial activity of Calophyllum bicolor and hemozoin crystals observed by Transmission Electron Microscope (TEM)

Jamilah Abbas;