publication . Article . 2017

Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells.

Min, Kyoung-jin; Nam, Ju-Ock; Kwon, Taeg Kyu;
Open Access
  • Published: 01 Aug 2017 Journal: Molecules, volume 22, page 1,285 (eissn: 1420-3049, Copyright policy)
  • Publisher: MDPI AG
Fisetin is a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions. Since fisetin can elicit anti-cancer effects, including anti-proliferation and anti-migration, we investigated whether fisetin induced apoptosis in human renal carcinoma (Caki) cells. Fisetin markedly induced sub-G1 population and cleavage of poly (ADP-ribose) polymerase (PARP), which is a marker of apoptosis, and increased caspase activation. We found that pan-caspase inhibitor (z-VAD-fmk) inhibited fisetin-induced apoptosis. In addition, fisetin induced death receptor 5 (DR5) expression at the transcriptional level, and down-regulation of DR5 by si...
free text keywords: fisetin, apoptosis, p53, DR5, renal carcinoma, Organic chemistry, QD241-441, Article
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