publication . Article . Other literature type . 2016

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse

Pagano, Ester; Capasso, Raffaele; Piscitelli, Fabiana; Romano, Barbara; Parisi, Olga A.; Finizio, Stefania; Lauritano, Anna; Marzo, Vincenzo Di; Izzo, Angelo A.; Borrelli, Francesca;
Open Access English
  • Published: 04 Oct 2016 Journal: Frontiers in Pharmacology (issn: 1663-9812, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Anecdotal and scientific evidence suggests that Cannabis use may be beneficial in inflammatory bowel disease (IBD) patients. Here, we have investigated the effect of a standardized Cannabis sativa extract with high content of cannabidiol (CBD), here named CBD BDS for “CBD botanical drug substance,” on mucosal inflammation and hypermotility in mouse models of intestinal inflammation. Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid (DNBS). Motility was evaluated in the experimental model of intestinal hypermotility induced by irritant croton oil. CBD BDS or pure CBD were given - either intraperitoneally or by oral gavage –...
Subjects
Medical Subject Headings: digestive system diseasesdigestive systemsurgical procedures, operative
free text keywords: Cannabidiol, Cannabinoids, Colitis, inflammatory bowel disease, intestinal motility, Cannabis sativa, Therapeutics. Pharmacology, RM1-950, Pharmacology, Original Research, Pharmacology (medical), medicine.disease, medicine, Inflammation, medicine.symptom, Intracolonic, Croton oil, business.industry, business, Diabetes mellitus, medicine.drug, Motility
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publication . Article . Other literature type . 2016

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse

Pagano, Ester; Capasso, Raffaele; Piscitelli, Fabiana; Romano, Barbara; Parisi, Olga A.; Finizio, Stefania; Lauritano, Anna; Marzo, Vincenzo Di; Izzo, Angelo A.; Borrelli, Francesca;