Differential Cellular Responses to Hedgehog Signalling in Vertebrates—What is the Role of Competence?

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Kiecker, Clemens; Graham, Anthony; Logan, Malcolm;
  • Publisher: MDPI
  • Journal: Journal of Developmental Biology,volume 4,issue 4 (issn: 2221-3759, eissn: 2221-3759)
  • Related identifiers: pmc: PMC5831800, doi: 10.3390/jdb4040036
  • Subject: limb bud | proliferation | temporal adaptation | neural tube | IRX | QH301-705.5 | morphogen | mouse | Drosophila | iroquois | Review | zebrafish | chick embryo | Biology (General)

A surprisingly small number of signalling pathways generate a plethora of cellular responses ranging from the acquisition of multiple cell fates to proliferation, differentiation, morphogenesis and cell death. These diverse responses may be due to the dose-dependent act... View more
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