publication . Article . Other literature type . 2018

Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models

Langsjoen, Rose M.; Haller, Sherry L.; Roy, Chad J.; Vinet-Oliphant, Heather; Bergren, Nicholas A.; Erasmus, Jesse H.; Livengood, Jill A.; Powell, Tim D.; Weaver, Scott C.; Rossi, Shannan L.;
Open Access English
  • Published: 06 Mar 2018 Journal: mBio (issn: 2150-7511, Copyright policy)
  • Publisher: American Society for Microbiology
Abstract
IMPORTANCE Chikungunya virus (CHIKV) is a reemerging human pathogen capable of causing debilitating and disfiguring polyarthritis, which can last for months to years after initial fever has resolved. There are four major genetic lineages of CHIKV, as well as two recently emerged sublineages, none of which have been evaluated for differences in virulence. Moreover, the ability of chikungunya vaccines to cross-protect against heterologous CHIKV lineages has not been explored. Therefore, we sought to compare the virulence levels among CHIKV lineages, as well as to evaluate the cross-protective efficacy of the CHIKV/IRESv1 vaccine candidate, in two different models ...
Subjects
Medical Subject Headings: virus diseases
free text keywords: Microbiology, QR1-502, Research Article, vaccine, Virology, Alphavirus, biology.organism_classification, biology, Virulence, Genetics, Primate, biology.animal, Chikungunya, medicine.disease_cause, medicine, Virus
Funded by
NIH| Novel Vaccine Technology for Chikungunya
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01AI093491-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Administrative Core
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U54AI057156-09
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| UTMB Clinical and Translational Science Award
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3UL1TR001439-04S2
  • Funding stream: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
,
NIH| World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R24AI120942-04
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Download fromView all 4 versions
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Article . 2018
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Article . 2018
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43 references, page 1 of 3

1.Powers AM, Brault AC, Tesh RB, Weaver SC 2000 Re-emergence of chikungunya and O’nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. J Gen Virol 81:471–479. doi:10.1099/0022-1317-81-2-471.10644846 [OpenAIRE] [PubMed] [DOI]

2.Tsetsarkin KA, Chen R, Sherman MB, Weaver SC 2011 Chikungunya virus: evolution and genetic determinants of emergence. Curr Opin Virol 1:310–317. doi:10.1016/j.coviro.2011.07.004.21966353 [OpenAIRE] [PubMed] [DOI]

3.Volk SM, Chen R, Tsetsarkin KA, Adams AP, Garcia TI, Sall AA, Nasar F, Schuh AJ, Holmes EC, Higgs S, Maharaj PD, Brault AC, Weaver SC 2010 Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates. J Virol 84:6497–6504. doi:10.1128/JVI.01603-09.20410280 [OpenAIRE] [PubMed] [DOI]

4.Sahadeo N, Mohammed H, Allicock OM, Auguste AJ, Widen SG, Badal K, Pulchan K, Foster JE, Weaver SC, Carrington CV 2015 Molecular characterisation of Chikungunya virus infections in Trinidad and comparison of clinical and laboratory features with dengue and other acute febrile cases. PLoS Negl Trop Dis 9:e0004199. doi:10.1371/journal.pntd.0004199.26580074 [OpenAIRE] [PubMed] [DOI]

5.Kautz TF, Díaz-González EE, Erasmus JH, Malo-García IR, Langsjoen RM, Patterson EI, Auguste DI, Forrester NL, Sanchez-Casas RM, Hernández-Ávila M, Alpuche-Aranda CM, Weaver SC, Fernández-Salas I 2015 Chikungunya virus as cause of febrile illness outbreak, Chiapas, Mexico, 2014. Emerg Infect Dis 21:2070–2073. doi:10.3201/eid2111.150546.26488312 [OpenAIRE] [PubMed] [DOI]

6.Teixeira MG, Andrade AM, Costa MDC, Castro JN, Oliveira FL, Goes CS, Maia M, Santana EB, Nunes BT, Vasconcelos PF 2015 East/Central/South African genotype chikungunya virus, Brazil, 2014. Emerg Infect Dis 21:906–907. doi:10.3201/eid2105.141727.25898939 [OpenAIRE] [PubMed] [DOI]

7.Tan KK, Sy AK, Tandoc AO, Khoo JJ, Sulaiman S, Chang LY, AbuBakar S 2015 Independent emergence of the Cosmopolitan Asian Chikungunya virus, Philippines 2012. Sci Rep 5:12279. doi:10.1038/srep12279.26201250 [OpenAIRE] [PubMed] [DOI]

8.Maurice D, Alain SM, Christophe V, Rene N, Irene KT, Marthe IN, Richard N 2015 Molecular characterization of chikungunya virus from three regions of Cameroon. Virol Sin 30:470–473. doi:10.1007/s12250-015-3663-7.26715303 [OpenAIRE] [PubMed] [DOI]

9.Moyen N, Thiberville SD, Pastorino B, Nougairede A, Thirion L, Mombouli JV, Dimi Y, Leparc-Goffart I, Capobianchi MR, Lepfoundzou AD, de Lamballerie X 2014 First reported chikungunya fever outbreak in the republic of Congo, 2011. PLoS One 9:e115938. doi:10.1371/journal.pone.0115938.25541718 [OpenAIRE] [PubMed] [DOI]

10.Chiam CW, Chan YF, Ong KC, Wong KT, Sam IC 2015 Neurovirulence comparison of chikungunya virus isolates of the Asian and East/Central/South African genotypes from Malaysia. J Gen Virol 96:3243–3254. doi:10.1099/jgv.0.000263.26276497 [OpenAIRE] [PubMed] [DOI]

11.Teo TH, Her Z, Tan JJ, Lum FM, Lee WW, Chan YH, Ong RY, Kam YW, Leparc-Goffart I, Gallian P, Rénia L, de Lamballerie X, Ng LF 2015 Caribbean and La Réunion Chikungunya virus isolates differ in their capacity to induce proinflammatory Th1 and NK cell responses and acute joint pathology. J Virol 89:7955–7969. doi:10.1128/JVI.00909-15.25995257 [OpenAIRE] [PubMed] [DOI]

12.Chen CI, Clark DC, Pesavento P, Lerche NW, Luciw PA, Reisen WK, Brault AC 2010 Comparative pathogenesis of epidemic and enzootic chikungunya viruses in a pregnant rhesus macaque model. Am J Trop Med Hyg 83:1249–1258. doi:10.4269/ajtmh.2010.10-0290.21118930 [OpenAIRE] [PubMed] [DOI]

13.Gardner J, Anraku I, Le TT, Larcher T, Major L, Roques P, Schroder WA, Higgs S, Suhrbier A 2010 Chikungunya virus arthritis in adult wild-type mice. J Virol 84:8021–8032. doi:10.1128/JVI.02603-09.20519386 [OpenAIRE] [PubMed] [DOI]

14.Brandler S, RuffiéC, Combredet C, Brault JB, Najburg V, Prevost MC, Habel A, Tauber E, Desprès P, Tangy F 2013 A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virus. Vaccine 31:3718–3725. doi:10.1016/j.vaccine.2013.05.086.23742993 [OpenAIRE] [PubMed] [DOI]

15.Ram sauer K, Schwameis M, Firbas C, Müllner M, Putnak RJ, Thomas SJ, Desprès P, Tauber E, Jilma B, Tangy F 2015 Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial. Lancet Infect Dis 15:519–527. doi:10.1016/S1473-3099(15)70043-5.25739878 [OpenAIRE] [PubMed] [DOI]

43 references, page 1 of 3
Abstract
IMPORTANCE Chikungunya virus (CHIKV) is a reemerging human pathogen capable of causing debilitating and disfiguring polyarthritis, which can last for months to years after initial fever has resolved. There are four major genetic lineages of CHIKV, as well as two recently emerged sublineages, none of which have been evaluated for differences in virulence. Moreover, the ability of chikungunya vaccines to cross-protect against heterologous CHIKV lineages has not been explored. Therefore, we sought to compare the virulence levels among CHIKV lineages, as well as to evaluate the cross-protective efficacy of the CHIKV/IRESv1 vaccine candidate, in two different models ...
Subjects
Medical Subject Headings: virus diseases
free text keywords: Microbiology, QR1-502, Research Article, vaccine, Virology, Alphavirus, biology.organism_classification, biology, Virulence, Genetics, Primate, biology.animal, Chikungunya, medicine.disease_cause, medicine, Virus
Funded by
NIH| Novel Vaccine Technology for Chikungunya
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01AI093491-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Administrative Core
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U54AI057156-09
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| UTMB Clinical and Translational Science Award
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3UL1TR001439-04S2
  • Funding stream: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
,
NIH| World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R24AI120942-04
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Download fromView all 4 versions
mBio
Article . 2018
mBio
Article . 2018
Provider: Crossref
mBio
Article
Provider: UnpayWall
43 references, page 1 of 3

1.Powers AM, Brault AC, Tesh RB, Weaver SC 2000 Re-emergence of chikungunya and O’nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. J Gen Virol 81:471–479. doi:10.1099/0022-1317-81-2-471.10644846 [OpenAIRE] [PubMed] [DOI]

2.Tsetsarkin KA, Chen R, Sherman MB, Weaver SC 2011 Chikungunya virus: evolution and genetic determinants of emergence. Curr Opin Virol 1:310–317. doi:10.1016/j.coviro.2011.07.004.21966353 [OpenAIRE] [PubMed] [DOI]

3.Volk SM, Chen R, Tsetsarkin KA, Adams AP, Garcia TI, Sall AA, Nasar F, Schuh AJ, Holmes EC, Higgs S, Maharaj PD, Brault AC, Weaver SC 2010 Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates. J Virol 84:6497–6504. doi:10.1128/JVI.01603-09.20410280 [OpenAIRE] [PubMed] [DOI]

4.Sahadeo N, Mohammed H, Allicock OM, Auguste AJ, Widen SG, Badal K, Pulchan K, Foster JE, Weaver SC, Carrington CV 2015 Molecular characterisation of Chikungunya virus infections in Trinidad and comparison of clinical and laboratory features with dengue and other acute febrile cases. PLoS Negl Trop Dis 9:e0004199. doi:10.1371/journal.pntd.0004199.26580074 [OpenAIRE] [PubMed] [DOI]

5.Kautz TF, Díaz-González EE, Erasmus JH, Malo-García IR, Langsjoen RM, Patterson EI, Auguste DI, Forrester NL, Sanchez-Casas RM, Hernández-Ávila M, Alpuche-Aranda CM, Weaver SC, Fernández-Salas I 2015 Chikungunya virus as cause of febrile illness outbreak, Chiapas, Mexico, 2014. Emerg Infect Dis 21:2070–2073. doi:10.3201/eid2111.150546.26488312 [OpenAIRE] [PubMed] [DOI]

6.Teixeira MG, Andrade AM, Costa MDC, Castro JN, Oliveira FL, Goes CS, Maia M, Santana EB, Nunes BT, Vasconcelos PF 2015 East/Central/South African genotype chikungunya virus, Brazil, 2014. Emerg Infect Dis 21:906–907. doi:10.3201/eid2105.141727.25898939 [OpenAIRE] [PubMed] [DOI]

7.Tan KK, Sy AK, Tandoc AO, Khoo JJ, Sulaiman S, Chang LY, AbuBakar S 2015 Independent emergence of the Cosmopolitan Asian Chikungunya virus, Philippines 2012. Sci Rep 5:12279. doi:10.1038/srep12279.26201250 [OpenAIRE] [PubMed] [DOI]

8.Maurice D, Alain SM, Christophe V, Rene N, Irene KT, Marthe IN, Richard N 2015 Molecular characterization of chikungunya virus from three regions of Cameroon. Virol Sin 30:470–473. doi:10.1007/s12250-015-3663-7.26715303 [OpenAIRE] [PubMed] [DOI]

9.Moyen N, Thiberville SD, Pastorino B, Nougairede A, Thirion L, Mombouli JV, Dimi Y, Leparc-Goffart I, Capobianchi MR, Lepfoundzou AD, de Lamballerie X 2014 First reported chikungunya fever outbreak in the republic of Congo, 2011. PLoS One 9:e115938. doi:10.1371/journal.pone.0115938.25541718 [OpenAIRE] [PubMed] [DOI]

10.Chiam CW, Chan YF, Ong KC, Wong KT, Sam IC 2015 Neurovirulence comparison of chikungunya virus isolates of the Asian and East/Central/South African genotypes from Malaysia. J Gen Virol 96:3243–3254. doi:10.1099/jgv.0.000263.26276497 [OpenAIRE] [PubMed] [DOI]

11.Teo TH, Her Z, Tan JJ, Lum FM, Lee WW, Chan YH, Ong RY, Kam YW, Leparc-Goffart I, Gallian P, Rénia L, de Lamballerie X, Ng LF 2015 Caribbean and La Réunion Chikungunya virus isolates differ in their capacity to induce proinflammatory Th1 and NK cell responses and acute joint pathology. J Virol 89:7955–7969. doi:10.1128/JVI.00909-15.25995257 [OpenAIRE] [PubMed] [DOI]

12.Chen CI, Clark DC, Pesavento P, Lerche NW, Luciw PA, Reisen WK, Brault AC 2010 Comparative pathogenesis of epidemic and enzootic chikungunya viruses in a pregnant rhesus macaque model. Am J Trop Med Hyg 83:1249–1258. doi:10.4269/ajtmh.2010.10-0290.21118930 [OpenAIRE] [PubMed] [DOI]

13.Gardner J, Anraku I, Le TT, Larcher T, Major L, Roques P, Schroder WA, Higgs S, Suhrbier A 2010 Chikungunya virus arthritis in adult wild-type mice. J Virol 84:8021–8032. doi:10.1128/JVI.02603-09.20519386 [OpenAIRE] [PubMed] [DOI]

14.Brandler S, RuffiéC, Combredet C, Brault JB, Najburg V, Prevost MC, Habel A, Tauber E, Desprès P, Tangy F 2013 A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virus. Vaccine 31:3718–3725. doi:10.1016/j.vaccine.2013.05.086.23742993 [OpenAIRE] [PubMed] [DOI]

15.Ram sauer K, Schwameis M, Firbas C, Müllner M, Putnak RJ, Thomas SJ, Desprès P, Tauber E, Jilma B, Tangy F 2015 Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial. Lancet Infect Dis 15:519–527. doi:10.1016/S1473-3099(15)70043-5.25739878 [OpenAIRE] [PubMed] [DOI]

43 references, page 1 of 3
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