publication . Article . Other literature type . 2018

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Ricketts, Christopher J.; De Cubas, Aguirre A.; Fan, Huihui; Smith, Christof C.; Lang, Martin; Reznik, Ed; Bowlby, Reanne; Gibb, Ewan A.; Akbani, Rehan; Beroukhim, Rameen; ...
Open Access English
  • Published: 01 Apr 2018
  • Publisher: Elsevier B.V.
  • Country: Italy
Abstract
Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways corr...
Subjects
Medical Subject Headings: urologic and male genital diseasesneoplasms
free text keywords: CDKN2A; chromatin remodeling; chromophobe renal cell carcinoma; clear cell renal cell carcinoma; DNA hypermethylation; immune signature; PanCanAtlas; papillary renal cell carcinoma; TCGA; Biochemistry, Genetics and Molecular Biology (all), General Biochemistry, Genetics and Molecular Biology, CDKN2A, chromatin remodeling, chromophobe renal cell carcinoma, clear cell renal cell carcinoma, DNA hypermethylation, immune signature, PanCanAtlas, papillary renal cell carcinoma, TCGA, Biomarkers, Tumor, Carcinoma, Renal Cell, Cyclin-Dependent Kinase Inhibitor p16, Humans, Kidney Neoplasms, Metabolic Networks and Pathways, Nuclear Proteins, PTEN Phosphohydrolase, Phenotype, Survival Analysis, Transcription Factors, Tumor Suppressor Proteins, Ubiquitin Thiolesterase, Genome, Human, Somatic point mutations; sequencing data; RNA-SEQ; lass discovery; messenger-RNA; kidney cancer; genetic-basis; expression; breast; DNA, Settore MED/27 - Neurochirurgia, Oncology, medicine.medical_specialty, medicine, Cancer genome, business.industry, business, Regret, Internal medicine, Cell, medicine.anatomical_structure, Renal cell carcinoma, medicine.disease, PBRM1, CDKN2A, Chromophobe cell, Clear cell renal cell carcinoma, Papillary renal cell carcinomas, BAP1, Chromophobe Renal Cell Carcinoma, Biology, Cancer research, lcsh:Biology (General), lcsh:QH301-705.5
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