The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

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Ricketts, Christopher J.; De Cubas, Aguirre A.; Fan, Huihui; Smith, Christof C.; Lang, Martin; Reznik, Ed; Bowlby, Reanne; Gibb, Ewan A.; Akbani, Rehan; Beroukhim, Rameen; Bottaro, Donald P.; Choueiri, Toni K.; Gibbs, Richard A.; Godwin, Andrew K.; Haake, Scott; Hakimi, A. Ari; Henske, Elizabeth P.; Hsieh, James J.; Thai H., Ho; Kanchi, Rupa S.; Krishnan, Bhavani; Kwaitkowski, David J.; Lui, Wembin; Merino, Maria J.; Mills, Gordon B.; Myers, Jerome; Nickerson, Michael L.; Reuter, Victor E.; Schmidt, Laura S.; Shelley, C. Simon; ... view all 770 authors
(2018)
  • Publisher: Elsevier B.V.
  • Journal: Cell Reports (issn: 2211-1247)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.celrep.2018.03.075
  • Subject: CDKN2A; chromatin remodeling; chromophobe renal cell carcinoma; clear cell renal cell carcinoma; DNA hypermethylation; immune signature; PanCanAtlas; papillary renal cell carcinoma; TCGA; Biochemistry, Genetics and Molecular Biology (all) | Somatic point mutations; sequencing data; RNA-SEQ; lass discovery; messenger-RNA; kidney cancer; genetic-basis; expression; breast; DNA | Settore MED/27 - Neurochirurgia | Biology (General) | QH301-705.5
    mesheuropmc: urologic and male genital diseases | neoplasms

Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 4... View more