publication . Article . 2007

Sweet BV의 함량분석과 시술 부위별 LD50관찰

Ching-Seng Chu; Hee-Soo Park; Min-Ki Kim; Bae-Chun Cha; Eun Lee; Ki-Rok Kwon;
Open Access English
  • Published: 01 Jun 2007 Journal: Journal of Pharmacopuncture (issn: 2093-6966, eissn: 2234-6856, Copyright policy)
  • Publisher: Korean Pharmacopuncture Institute
Abstract
Objectives : This study was conducted to carry out quantitative evaluation and safety of Sweet Bee Venom. Methods : Content analysis was done using HPLC, measurement of LD50 was conducted intravenous, subcutaneous, and intra-muscular injection to the ICR mice. Results : 1. According to HPLC analysis, removal of the enzymes containing phospholipase A2 was successfully rendered on Sweet Bee Venom. And analyzing melittin content, Sweet Bee Venom contained 12% more melittin than Bee Venom. 2. LD50 of ICR mice with Sweet Bee Venom was more than 20mg/kg in subcutaneous injection and intravenous injection, between 15mg/kg and 20mg/kg in muscular injection. 3. LD50 of I...
Subjects
Medical Subject Headings: complex mixturesfungibehavior and behavior mechanismsanimal diseases
free text keywords: Sweet Bee Venom, Bee Venom, LD50, HPLC analysis, melittin, Medicine, R, Miscellaneous systems and treatments, RZ409.7-999, Therapeutics. Pharmacology, RM1-950, Pharmacology, chemistry.chemical_compound, chemistry, Venom, business.industry, business, High-performance liquid chromatography, Anesthesia, Median lethal dose
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