Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo

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Clémence Roux; Clémence Roux; Clémence Roux; Gaëlle Saviane; Gaëlle Saviane; Jonathan Pini; Jonathan Pini; Nourhène Belaïd; Nourhène Belaïd; Gihen Dhib; Gihen Dhib; Christine Voha; Christine Voha; Christine Voha; Lidia Ibáñez; Lidia Ibáñez; Antoine Boutin; Antoine Boutin; Nathalie M. Mazure; Nathalie M. Mazure; Abdelilah Wakkach; Abdelilah Wakkach; Claudine Blin-Wakkach; Claudine Blin-Wakkach; Matthieu Rouleau; Matthieu Rouleau;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Immunology (issn: 1664-3224)
  • Related identifiers: doi: 10.3389/fimmu.2017.01991/full, doi: 10.3389/fimmu.2017.01991
  • Subject: induced pluripotent stem cells | mesenchymal stromal cells | human T-cell immunosuppression | regulatory T cells | humanized NSG mouse | tolerance | Immunologic diseases. Allergy | RC581-607

Despite mesenchymal stromal cells (MSCs) are considered as a promising source of cells to modulate immune functions on cells from innate and adaptive immune systems, their clinical use remains restricted (few number, limited in vitro expansion, absence of a full phenoty... View more
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