Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity

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Das, Suvankar; da Silva, Cristiane J.; Silva, Marina de M.; Dantas, Maria Dayanne de A.; de Fátima, Ângelo; Góis Ruiz, Ana Lúcia T.; da Silva, Cleiton M.; de Carvalho, João Ernesto; Santos, Josué C.C.; Figueiredo, Isis M.; da Silva-Júnior, Edeildo F.; de Aquino, Thiago M.; de Araújo-Júnior, João X.; Brahmachari, Goutam; Modolo, Luzia Valentina;
(2017)
  • Publisher: Elsevier
  • Journal: Journal of Advanced Research,volume 9,pages51-61 (issn: 2090-1232, eissn: 2090-1224)
  • Related identifiers: pmc: PMC6057241, doi: 10.1016/j.jare.2017.10.010
  • Subject: Original Article | R5-920 | Science (General) | Q1-390 | Medicine (General) | Anticancer activity | Piperidine derivatives | DNA interaction | Free radical scavenging

Twenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA using spectroscopic techniques was also evaluated. Our results demonstrate that the evaluated piperidines possesses different abil... View more
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