publication . Article . 2017

Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity.

Das, Suvankar; da Silva, Cristiane J.; Silva, Marina de M.; Dantas, Maria Dayanne de A.; de Fátima, Ângelo; Góis Ruiz, Ana Lúcia T.; da Silva, Cleiton M.; de Carvalho, João Ernesto; Santos, Josué C.C.; Figueiredo, Isis M.; ...
  • Published: 01 Oct 2017
  • Publisher: Elsevier BV
Abstract
Graphical abstract
Subjects
ACM Computing Classification System: ComputingMethodologies_COMPUTERGRAPHICS
free text keywords: Scavenger, Chromatography, Piperidine, chemistry.chemical_compound, chemistry, DPPH, Intercalation (chemistry), Stereochemistry, HaCaT, Combinatorial chemistry, Superoxide, Biological activity, Cell culture, Piperidine derivatives, Free radical scavenging, Anticancer activity, DNA interaction, Medicine (General), R5-920, Science (General), Q1-390, Original Article
61 references, page 1 of 5

Behenna, D.C., Liu, Y., Yurino, T., Kim, J., White, D.E., Virgil, S.C.. Enantioselective construction of quaternary N-heterocycles by palladium-catalyzed decarboxylative allylic alkylation of lactams. Nat Chem. 2012; 4 (2): 130-133

Patil, P.O., Bari, S.B.. Nitrogen heterocycles as potential monoamine oxidase inhibitors: synthetic aspects. Arab J Chem. 2014; 7: 857-884

Petit, S., Nallet, J.P., Guillard, M., Dreux, J., Chermat, R., Poncelet, M.. Synthèses et activités psychotropes de 3,4-diarylpipéridines. Corrélation structure-activité et recherche d'une activité antihypertensive. Eur J Med Chem. 1991; 26: 19-32

Zhou, Y., Gregor, V.E., Ayida, B.K., Winters, G.C., Sun, Z., Murphy, D.. Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics. Bioorg Med Chem Lett. 2007; 17: 1206-1210 [OpenAIRE] [PubMed]

Misra, M., Pandey, S.K., Pandey, V.P., Pandey, J., Tripathi, R., Tripathi, R.P.. Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials. Bioorg Med Chem. 2009; 17: 625-633 [OpenAIRE] [PubMed]

Ho, B., Crider, A.M., Stables, J.P.. Synthesis and structure–activity relationships of potential anticonvulsants based on 2-piperidinecarboxylic acid and related pharmacophores. Eur J Med Chem. 2001; 36: 265-286 [OpenAIRE] [PubMed]

Rao, K.N., Redda, K.K., Onayemi, F.Y., Melles, H., Choi, J.. Synthesis of some N-[pyridyl(phenyl)carbonylamino]hydroxyalkyl-(benzyl)-1,2,3,6-tetrahydropyridines as potential anti-inflammatory agents. J Heterocycl Chem. 1995; 32: 307-315

Gangapuram, M., Redda, K.K.. Synthesis of 1-(substituted phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as potential anti-inflammatory agents. J Heterocycl Chem. 2006; 43: 709-718 [OpenAIRE] [PubMed]

Ravindernath, A., Reddy, M.S.. Synthesis and evaluation of anti-inflammatory, antioxidant and antimicrobial activities of densely functionalized novel benzo [d] imidazolyl tetrahydropyridine carboxylates. Arab J Chem. 2017; 10: S1172-S1179 [OpenAIRE]

Aeluri, R., Alla, M., Bommena, V.R., Murthy, R., Jain, N.. Synthesis and antiproliferative activity of polysubstituted tetrahydropyridine and piperidin-4-one-3-carboxylate derivatives. Asian J Org Chem. 2012; 1: 71-79

Wilkinson, D.G.. The pharmacology of donepezil: a new treatment for Alzheimer’s disease. Expert Opin Pharmacother. 1999; 1 (1): 121-135 [PubMed]

Schotte, A., Janssen, P.F.M., Gommeren, W., Luyten, W.H.M.L., Van Gompel, P., Lesage, A.S.. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology. 1996; 124: 57-73 [OpenAIRE] [PubMed]

Kosjek, T., Dolinšek, T., Gramec, D., Heath, E., Strojan, P., Serša, G.. Determination of vinblastine in tumour tissue with liquid chromatography–high resolution mass spectrometry. Talanta. 2013; 116: 887-893 [OpenAIRE] [PubMed]

Brahmachari, G., Das, S.. Bismuth nitrate-catalyzed multicomponent reaction for efficient and one-pot synthesis of densely functionalized piperidine scaffolds at room temperature. Tetrahedron Lett. 2012; 53: 1479-1484 [OpenAIRE]

Gülçin, I.. Antioxidant properties of resveratrol: a structure-activity insight. Innovat Food Sci Emerg Tech. 2010; 11: 210-218

61 references, page 1 of 5
Abstract
Graphical abstract
Subjects
ACM Computing Classification System: ComputingMethodologies_COMPUTERGRAPHICS
free text keywords: Scavenger, Chromatography, Piperidine, chemistry.chemical_compound, chemistry, DPPH, Intercalation (chemistry), Stereochemistry, HaCaT, Combinatorial chemistry, Superoxide, Biological activity, Cell culture, Piperidine derivatives, Free radical scavenging, Anticancer activity, DNA interaction, Medicine (General), R5-920, Science (General), Q1-390, Original Article
61 references, page 1 of 5

Behenna, D.C., Liu, Y., Yurino, T., Kim, J., White, D.E., Virgil, S.C.. Enantioselective construction of quaternary N-heterocycles by palladium-catalyzed decarboxylative allylic alkylation of lactams. Nat Chem. 2012; 4 (2): 130-133

Patil, P.O., Bari, S.B.. Nitrogen heterocycles as potential monoamine oxidase inhibitors: synthetic aspects. Arab J Chem. 2014; 7: 857-884

Petit, S., Nallet, J.P., Guillard, M., Dreux, J., Chermat, R., Poncelet, M.. Synthèses et activités psychotropes de 3,4-diarylpipéridines. Corrélation structure-activité et recherche d'une activité antihypertensive. Eur J Med Chem. 1991; 26: 19-32

Zhou, Y., Gregor, V.E., Ayida, B.K., Winters, G.C., Sun, Z., Murphy, D.. Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics. Bioorg Med Chem Lett. 2007; 17: 1206-1210 [OpenAIRE] [PubMed]

Misra, M., Pandey, S.K., Pandey, V.P., Pandey, J., Tripathi, R., Tripathi, R.P.. Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials. Bioorg Med Chem. 2009; 17: 625-633 [OpenAIRE] [PubMed]

Ho, B., Crider, A.M., Stables, J.P.. Synthesis and structure–activity relationships of potential anticonvulsants based on 2-piperidinecarboxylic acid and related pharmacophores. Eur J Med Chem. 2001; 36: 265-286 [OpenAIRE] [PubMed]

Rao, K.N., Redda, K.K., Onayemi, F.Y., Melles, H., Choi, J.. Synthesis of some N-[pyridyl(phenyl)carbonylamino]hydroxyalkyl-(benzyl)-1,2,3,6-tetrahydropyridines as potential anti-inflammatory agents. J Heterocycl Chem. 1995; 32: 307-315

Gangapuram, M., Redda, K.K.. Synthesis of 1-(substituted phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as potential anti-inflammatory agents. J Heterocycl Chem. 2006; 43: 709-718 [OpenAIRE] [PubMed]

Ravindernath, A., Reddy, M.S.. Synthesis and evaluation of anti-inflammatory, antioxidant and antimicrobial activities of densely functionalized novel benzo [d] imidazolyl tetrahydropyridine carboxylates. Arab J Chem. 2017; 10: S1172-S1179 [OpenAIRE]

Aeluri, R., Alla, M., Bommena, V.R., Murthy, R., Jain, N.. Synthesis and antiproliferative activity of polysubstituted tetrahydropyridine and piperidin-4-one-3-carboxylate derivatives. Asian J Org Chem. 2012; 1: 71-79

Wilkinson, D.G.. The pharmacology of donepezil: a new treatment for Alzheimer’s disease. Expert Opin Pharmacother. 1999; 1 (1): 121-135 [PubMed]

Schotte, A., Janssen, P.F.M., Gommeren, W., Luyten, W.H.M.L., Van Gompel, P., Lesage, A.S.. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology. 1996; 124: 57-73 [OpenAIRE] [PubMed]

Kosjek, T., Dolinšek, T., Gramec, D., Heath, E., Strojan, P., Serša, G.. Determination of vinblastine in tumour tissue with liquid chromatography–high resolution mass spectrometry. Talanta. 2013; 116: 887-893 [OpenAIRE] [PubMed]

Brahmachari, G., Das, S.. Bismuth nitrate-catalyzed multicomponent reaction for efficient and one-pot synthesis of densely functionalized piperidine scaffolds at room temperature. Tetrahedron Lett. 2012; 53: 1479-1484 [OpenAIRE]

Gülçin, I.. Antioxidant properties of resveratrol: a structure-activity insight. Innovat Food Sci Emerg Tech. 2010; 11: 210-218

61 references, page 1 of 5
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