publication . Article . 2013

Determining Minimal Clinically Important Differences in Japanese Cedar/Cypress Pollinosis Patients

Haruka Hirai; Shin Kariya; Shuji Yonekura; Kimihiro Okubo; Minoru Gotoh; Takenori Haruna; Aya Murai; Takaya Higaki; Tazuko Fujiwara; Kazunori Nishizaki; ...
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  • Published: 01 Jan 2013 Journal: Allergology International (issn: 1323-8930, Copyright policy)
  • Publisher: Elsevier
Abstract
ABSTRACT Background Statistically significant results of medical intervention trials are not always clinically meaningful. We sought to estimate the minimal clinically important difference (MCID) (the smallest change in a given endpoint that is meaningful to a patient) during seasonal alteration of Japanese cedar/cypress pollinosis (JCCP). Methods Results of a double-blinded, placebo-controlled trial of JCCP patients conducted between 2008 and 2010 were analyzed using an anchor-based method in which a face scale for Japanese rhinoconjunctivitis quality-of-life questionnaire (JRQLQ) was set as an anchor. MICDs were calculated as changes of average scores, includi...
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doi: 10.2332/allergolint.13-oa-0570
Subjects
Medical Subject Headings: humanities
free text keywords: face scale, minimal clinically important difference, pollinosis, quality of life, symptom score, Immunologic diseases. Allergy, RC581-607, Immunology and Allergy, General Medicine, Internal medicine, medicine.medical_specialty, medicine, Intervention trials, Pathology, Cypress, business.industry, business
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