publication . Article . 2006

Elimination of IL-13 Reverses Established Goblet Cell Metaplasia into Ciliated Epithelia in Airway Epithelial Cell Culture

Mitsuko Kondo; Jun Tamaoki; Kiyoshi Takeyama; Kazuo Isono; Kiyomi Kawatani; Takehiro Izumo; Atsushi Nagai;
Open Access English
  • Published: 01 Jan 2006 Journal: Allergology International (issn: 1323-8930, Copyright policy)
  • Publisher: Elsevier
Background: Interleukin (IL)-13 induces goblet cell metaplasia and plays an important role in mucus hypersecretion in asthma. We previously reported that IL-13 induced goblet cell differentiation along with less ciliated cell differentiation in guinea pig tracheal epithelial cells in vitro. In this study, we asked whether elimination of IL-13 could reverse the established goblet cell metaplasia into ciliated epithelia. Methods: Primary epithelial cells from guinea pig tracheas were cultured at an air-liquid interface with the medium containing human recombinant IL-13 for 14 days, and continuously cultured with IL-13-eliminated medium, or cultured under the co...
mesheuropmc: respiratory system
free text keywords: anti-IL-13 antibody, RC581-607, goblet cells, IL-13, Immunologic diseases. Allergy, ciliated cells, transition
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