Elimination of IL-13 Reverses Established Goblet Cell Metaplasia into Ciliated Epithelia in Airway Epithelial Cell Culture

Article English OPEN
Mitsuko Kondo ; Jun Tamaoki ; Kiyoshi Takeyama ; Kazuo Isono ; Kiyomi Kawatani ; Takehiro Izumo ; Atsushi Nagai (2006)
  • Publisher: Elsevier
  • Journal: Allergology International (issn: 1323-8930)
  • Related identifiers: doi: 10.2332/allergolint.55.329
  • Subject: anti-IL-13 antibody | RC581-607 | goblet cells | IL-13 | Immunologic diseases. Allergy | ciliated cells | transition
    mesheuropmc: respiratory system

Background: Interleukin (IL)-13 induces goblet cell metaplasia and plays an important role in mucus hypersecretion in asthma. We previously reported that IL-13 induced goblet cell differentiation along with less ciliated cell differentiation in guinea pig tracheal epith... View more
Share - Bookmark