publication . Other literature type . Article . 2018

Antioxidant and Anti-Osteoporosis Activities of Chemical Constituents of the Stems of Zanthoxylum piperitum

Seo Young Yang; Sang-Hyun Lee; Bui Huu Tai; Hae Dong Jang; Young Ho Kim;
Open Access
  • Published: 01 Feb 2018
  • Publisher: MDPI AG
Abstract
Two new lignans, zanthoxyloside C (1) and zanthoxyloside D (2), together with nine known compounds comprising lignans (3–5), flavonoids (6–8), and phenolics (9–11), were isolated from the methanol extract of the stems of Zanthoxylum piperitum. All isolates were evaluated for their antioxidant and anti-osteoporotic activities using oxygen radical absorbance capacity (ORAC), cupric reducing antioxidant capacity (CUPRAC), and tartrate-resistant acid phosphatase (TRAP) assays. Compounds 7–10 showed peroxyl radical-scavenging capacities and 4, 6–7, and 9 showed reducing capacities. Moreover, compounds 3, 6–9, and 11 significantly suppressed TRAP activities. These res...
Persistent Identifiers
Subjects
free text keywords: Zanthoxylum piperitum, Antioxidant, Anti-osteoporosis, ORAC, CUPRAC, TRAP, Organic Chemistry, Article, lcsh:Organic chemistry, lcsh:QD241-441, Chemistry, Oxygen radical absorbance capacity, biology.organism_classification, biology, Methanol, chemistry.chemical_compound, Anti osteoporosis, medicine.medical_treatment, medicine, Chemical constituents, Acid phosphatase, biology.protein, Food science, Antioxidant capacity
Related Organizations
31 references, page 1 of 3

1. Harris, P.E.; Bouloux, P.-M.G. Metabolic Bone Disease. In Endocrinology in Practice, 2nd ed.; Harris, P.E., Bouloux, P.-M.G., Eds.; CRC Press: London, UK, 2014; pp. 243-261. ISBN 978-1841849515.

2. Rosen, C.J.; Bouxsein, M.L. Mechanisms of Disease: Is Osteoporosis the Obesity of Bone? Nat. Clin. Pract. Rheumatol. 2006, 2, 35-43. [CrossRef] [PubMed]

3. Teitelbaum, S.L. Bone Resorption by Osteoclasts. Science 2000, 289, 1504-1508. [CrossRef] [PubMed] [OpenAIRE]

4. Parfitt, A.; Mathews, C.; Villanueva, A.; Kleerekoper, M.; Frame, B.; Rao, D. Relationships between Surface, Volume, and Thickness of Iliac Trabecular Bone in Aging and in Osteoporosis. Implications for the Microanatomic and Cellular Mechanisms of Bone Loss. J. Clin. Investig. 1983, 72, 1396-1409. [CrossRef] [PubMed] [OpenAIRE]

5. Srivastava, M.; Deal, C. Osteoporosis in Elderly: Prevention and Treatment. Clin. Geriatr. Med. 2002, 18, 529-555. [CrossRef] [OpenAIRE]

6. Basu, S.; Michaëlsson, K.; Olofsson, H.; Johansson, S.; Melhus, H. Association Between Oxidative Stress and Bone Mineral Density. Biochem. Biophys. Ress Communs. 2001, 288, 275-279. [CrossRef] [PubMed] [OpenAIRE]

7. Maggio, D.; Barabani, M.; Pierandrei, M.; Polidori, M.C.; Catani, M.; Mecocci, P.; Senin, U.; Pacifici, R.; Cherubini, A. Marked Decrease in Plasma Antioxidants in Aged Osteoporotic women: Results of a Cross-Sectional Study. J. Clin. Endocrinol. Metab. 2003, 88, 1523-1527. [CrossRef] [PubMed]

8. Morton, D.J.; Barrett-Connor, E.L.; Schneider, D.L. Vitamin c Supplement Use and Bone Mineral Density in Postmenopausal Women. J. Bone. Miner. Res. 2001, 16, 135-140. [CrossRef] [PubMed]

9. Hatano, T.; Inada, K.; Ogawa, T.-o.; Ito, H.; Yoshida, T. Aliphatic Acid Amides of the Fruits of Zanthoxylum piperitum. Phytochemistry. 2004, 65, 2599-2604. [CrossRef] [PubMed]

10. Jiang, L.; Kubota, K. Formation by Mechanical Stimulus of the Flavor Compounds in Young Leaves of Japanese Pepper (Xanthoxylum piperitum DC.). J. Agric. Food Chem. 2001, 49, 1353-1357. [CrossRef] [PubMed]

11. Sakai, T.; Yoshihara, K.; Hirose, Y. Constituents of Fruit Oil from Japanese Pepper. Bull. Chem. Soc. Jap. 1968, 41, 1945-1950. [CrossRef]

12. Machmudah, S.; Izumi, T.; Sasaki, M.; Goto, M. Extraction of Pungent Components from Japanese Pepper (Xanthoxylum piperitum DC.) Using Supercritical CO2. Sep. Purif. Technol. 2009, 68, 159-164. [CrossRef]

13. Kikuchi, M.; Kikuchi, M. Studies on the Constituents of Swertia japonica Makino II. On the Structures of New Glycosides. Chem. Pharm. Bull. 2005, 53, 48-51. [CrossRef] [PubMed]

14. Cai, X.F.; Lee, I.S.; Dat, N.T.; Shen, G.; Kang, J.S.; Kim, D.H.; Kim, Y.H. Inhibitory Lignans Against NFAT Transcription Factor from Acanthopanax koreanum. Arch. Pharm. Res. 2004, 27, 738-741. [CrossRef] [PubMed]

15. Nan, H.; Lin, H.; Qian, Z. Two New Furofuran Lignans from Kandelia obovata. Heterocycl. Int. J. Rev. Commun. Heterocycl. Chem. 2013, 87, 1093-1098. [CrossRef]

31 references, page 1 of 3
Any information missing or wrong?Report an Issue