publication . Article . 2015

Simultaneous diagnosis and drug delivery by silymarin-loaded magnetic nanoparticles

Farhad Khoeini;
Open Access English
  • Published: 01 Jul 2015 Journal: Nanomedicine Journal (issn: 2322-3049, eissn: 2322-5904, Copyright policy)
  • Publisher: Mashhad University of Medical Sciences
Objective(s): The aim of this work was to prepare and characterize magnetic nanoparticles (MNPs) as theranostic system to act simultaneously as drug carrier and MRI contrast agent. Chitosan-coated MNPs (CMNPs) were prepared and loaded with silymarin. Silymarin-loaded CMNPs were characterized with various techniques and their potential as MRI contrast agent was also evaluated. Materials and Methods:The chitosan-coated MNPs were prepared by coprecipitation method and were loaded with silymarin. The synthesized nanoparticles were characterized by various techniques including SEM, TEM, X‐ray diffraction (XRD), FTIR and vibrating sample magnetometer (VSM). In vitro d...
free text keywords: Chitosan, Drug delivery systems, Magnetite, MRI contrast agent, Silymarin, Medicine (General), R5-920
Related Organizations
30 references, page 1 of 2

1. Pankhurst QA, Connolly J, Jones S, Dobson J. Applications of magnetic nanoparticles in biomedicine. J Phys D: Appl Phys. 2003; 36(13): R167.

2. Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials. 2005; 26(18): 3995-4021.

3. Shafi KV, Ulman A, Yan X, Yang N-L, Estournes C, White H, et al. Sonochemical synthesis of functionalized amorphous iron oxide nanoparticles. Langmuir. 2001; 17(16): 5093-7.

4. Fried T, Shemer G, Markovich G. Ordered Two Dimensional Arrays of Ferrite Nanoparticles. Adv Mater. 2001; 13(15): 1158-61.

5. Mai TTT, Ha PT, Pham HN, Le TTH, Pham HL, Phan TBH, et al. Chitosan and O-carboxymethyl chitosan modified Fe3O4 for hyperthermic treatment. Adv Nat Sci: Nanosci Nanotechnol. 2012; 3(1): 015006.

6. Ali I, Salim K, A Rather M, A Wani W, Haque A. Advances in nano drugs for cancer chemotherapy. Current cancer drug targets. 2011; 11(2): 135-46.

7. Shenoy DB, Amiji MM. Poly (ethylene oxide)-modified poly ([- caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer. Int J Pharm. 2005; 293(1): 261-70. [OpenAIRE]

8. Safra T, Muggia F, Jeffers S, Tsao-Wei D, Groshen S, Lyass O, et al. Pegylated liposomal doxorubicin (doxil): reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2. Ann Oncol. 2000; 11(8): 1029-33. [OpenAIRE]

9. Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm. 2008; 5(4): 505-15.

10. Grassi-Schultheiss P, Heller F, Dobson J. Analysis of magnetic material in the human heart, spleen and liver. Biometals. 1997; 10(4): 351-5.

11. Hu F, Neoh K, Kang E. Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles. Biomaterials. 2006; 27(33): 5725-33.

12. DerMarderosian A, Beutler JA. The review of natural products: the most complete source of natural product information: Facts and Comparisons; 2002.

13. Evans W. Trease and Evans pharmacognosy (2002). WB Saunders, China.193-407.

14. Das SK, Mukherjee S, Vasudevan D. Medicinal properties of milk thistle with special reference to silymarin: An overview. Nat Prod Rad. 2008; 7: 182-92.

15. Kshirsagar A, Ingawale D, Ashok P, Vyawahare N. Silymarin: a comprehensive review. Pharmacogn Rev. 2009;3(5):116- 24.

30 references, page 1 of 2
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2015

Simultaneous diagnosis and drug delivery by silymarin-loaded magnetic nanoparticles

Farhad Khoeini;