publication . Article . 2009

Microbial transformation of sesquitepenoid ketone, (+) Nootkatone by Macrophomia phaseolina

Vajira P. Bulugahapitiya; Syed Ghulam Musharaff;
Open Access English
  • Published: 01 Sep 2009 Journal: Ruhuna Journal of Science (issn: 1800-279X, Copyright policy)
  • Publisher: University of Ruhuna
Microbial transformation is an effective tool for the structural modification of bioactive natural and synthetic compounds leading to synthesis of more potent derivatives. Its application in asymmetric synthesis is increasing due to its versatility and ease. This article presents biotransformation of sesquiterpenoid ketone, (+)-Nootkatone (1) by M. phaseolina, a plant pathogenic fungus. The transformation afforded four main compounds. They were determined to be 1:6 stereoisomeric mixture of 11,12-dihydroxy- 11,12-dihydronootkatone (2, 3), 13-hydroxynootkaone (4) and 12-hydroxy-11,12- dihydronootkatone (5) with the help of EI-MS, HR-FAB-MS(pos), HR-FAB-MS (neg), ...
free text keywords: Microbial transformation, Nootkatone, M. phaseolina, Science (General), Q1-390
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