publication . Article . 2012

Correlation between HER2 gene amplification and protein overexpression through fluorescence in situ hybridization and immunohistochemistry in breast carcinoma patients

Raj Nath Makroo; Mohit Chowdhry; Manoj Kumar; Priyanka Srivastava; Richa Tyagi; Preeti Bhadauria; Sumaid Kaul; Ramesh Sarin; Pratap Kishore Das; Harsh Dua;
Open Access
  • Published: 01 Jan 2012 Journal: Indian Journal of Pathology and Microbiology, volume 55, page 481 (issn: 0377-4929, Copyright policy)
  • Publisher: Medknow
Abstract
Background : In India, the incidence of breast cancer has increased in the urban population, with 1 in every 22 women diagnosed with breast cancer. It is important to know the HER2/neu gene status for a better prognostication of these patients. Aim : The aim of this study was to compare the efficacy of fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) for determining HER2/neu alteration in breast carcinoma. Materials and Methods : A total of 188 histologically proven breast carcinoma cases between the years 2007 and 2011 were retrospectively analyzed on the paraffin tissue sections by both IHC and FISH techniques. FISH for HER2/neu gene am...
Persistent Identifiers
Subjects
Medical Subject Headings: skin and connective tissue diseases
free text keywords: Pathology and Forensic Medicine, Microbiology (medical), General Medicine, IHC, Population, education.field_of_study, education, Breast carcinoma, Breast cancer, medicine.disease, medicine, HER2/neu, biology.protein, biology, Immunohistochemistry, Pathology, medicine.medical_specialty, Protein overexpression, Fluorescence in situ hybridization, medicine.diagnostic_test, Gene duplication, lcsh:Pathology, lcsh:RB1-214, lcsh:Microbiology, lcsh:QR1-502
Any information missing or wrong?Report an Issue