publication . Article . 2012

Correlation between HER2 gene amplification and protein overexpression through fluorescence in situ hybridization and immunohistochemistry in breast carcinoma patients

Mohit Chowdhry; Manoj Kumar; Priyanka Srivastava; Richa Tyagi; Preeti Bhadauria; Sumaid Kaul; Ramesh Sarin; PK Das; Harsh Dua; RN Makroo;
Open Access English
  • Published: 01 Jan 2012 Journal: Indian Journal of Pathology and Microbiology (issn: 0377-4929, Copyright policy)
  • Publisher: Wolters Kluwer Medknow Publications
Abstract
Background : In India, the incidence of breast cancer has increased in the urban population, with 1 in every 22 women diagnosed with breast cancer. It is important to know the HER2/neu gene status for a better prognostication of these patients. Aim : The aim of this study was to compare the efficacy of fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) for determining HER2/neu alteration in breast carcinoma. Materials and Methods : A total of 188 histologically proven breast carcinoma cases between the years 2007 and 2011 were retrospectively analyzed on the paraffin tissue sections by both IHC and FISH techniques. FISH for HER2/neu gene am...
Subjects
Medical Subject Headings: skin and connective tissue diseases
free text keywords: Breast carcinoma, fluorescence in situ hybridization, HER2/neu, IHC, Pathology, RB1-214, Microbiology, QR1-502, Pathology and Forensic Medicine, Microbiology (medical), General Medicine, Carcinoma, medicine.disease, medicine, Breast cancer, Gene duplication, Immunohistochemistry, medicine.medical_specialty, Protein overexpression, medicine.diagnostic_test, biology.protein, biology, Population, education.field_of_study, education, business.industry, business
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publication . Article . 2012

Correlation between HER2 gene amplification and protein overexpression through fluorescence in situ hybridization and immunohistochemistry in breast carcinoma patients

Mohit Chowdhry; Manoj Kumar; Priyanka Srivastava; Richa Tyagi; Preeti Bhadauria; Sumaid Kaul; Ramesh Sarin; PK Das; Harsh Dua; RN Makroo;