publication . Article . 2014

Discussion on the establishment of blood glucose fluctuation animal models

Chun-Liu Gai; Jing-Ru Zhao; Xiao-Long Chen;
Open Access English
  • Published: 01 Apr 2014 Journal: Guoji Yanke Zazhi (issn: 1672-5123, eissn: 1672-5123, Copyright policy)
  • Publisher: Press of International Journal of Ophthalmology (IJO PRESS)
Abstract
AIM: To provide the experimental basis for the <i>in vivo</i> study of blood glucose fluctuation injury mechanism, through intraperitoneal injection of glucose to establish blood glucose fluctuation animal models and to simulate blood glucose fluctuation of patients with diabetes.<p>METHODS: Rats were randomly divided into four groups: normal control group(NC), normal fluctuation group(NF), diabetes mellitus group(DM)and diabetes fluctuation group(DF). Diabetic models were induced through intraperitoneal injection of STZ. A certain amount of glucose was injected in the rats of group NF and DF intraperitoneally three times a day after the model was established, t...
Subjects
free text keywords: diabetes mellitus, blood glucose fluctuation, animal model, animal model, Ophthalmology, RE1-994
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