publication . Article . 2017

Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution.

Merve Eryilmaz; Sebnem Yilmaz; Ugur Tamer; Ismail Hakki Boyaci; Ismail Hakki Boyaci; Haslet Eksi-Kocak; Sibel Ilbasmis Tamer;
Open Access English
  • Published: 01 Oct 2017 Journal: Asian Journal of Pharmaceutical Sciences, volume 13, issue 2, pages 155-162 (issn: 1818-0876, eissn: 2221-285X, Copyright policy)
  • Publisher: Shenyang Pharmaceutical University
Abstract
Graphical Abstract FT-Raman spectroscopy offers a useful method for mapping the active pharmaceutical ingredients in film tablets. The combination of FT-Raman mapping with MCR analysis provides to observe the distribution of salicylic acid content in film tablets and quantify the lower concentrations. Unlabelled image
Subjects
free text keywords: Original Research Article, Raman mapping, Multivariate curve resolution, FT-Raman spectroscopy, Salicylic acid, Therapeutics. Pharmacology, RM1-950, Analytical chemistry, Excipient, medicine.drug, medicine, Correlation coefficient, Chemistry, Active ingredient, Spectroscopy, Chromatography, chemistry.chemical_compound, Calibration curve, Raman spectroscopy, symbols.namesake, symbols, Detection limit
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