publication . Article . Other literature type . 2017

Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells

Dengke Bao; Jingkai Wang; Xiaobin Pang; Hongliang Liu;
Open Access
  • Published: 06 Jul 2017 Journal: Molecules, volume 22, page 1,122 (eissn: 1420-3049, Copyright policy)
  • Publisher: MDPI AG
Abstract
Oxidative stress has been implicated in the pathogenesis of many kinds of neurodegenerative disorders, particularly Parkinson’s disease. Quercetin is a bioflavonoid found ubiquitously in fruits and vegetables, and has antioxidative activity. However, the underlying mechanism of the antioxidative effect of quercetin in neurodegenerative diseases has not been well explored. Here, we investigated the antioxidative effect and underlying molecular mechanisms of quercetin on PC-12 cells. We found that PC-12 cells pretreated with quercetin exhibited an increased cell viability and reduced lactate dehydrogenase (LDH) release when exposed to hydrogen peroxide (H2O2). The...
Subjects
Medical Subject Headings: heterocyclic compounds
free text keywords: Catalase, biology.protein, biology, Viability assay, Quercetin, chemistry.chemical_compound, chemistry, Malondialdehyde, Organic chemistry, Biochemistry, Superoxide dismutase, Oxidative stress, medicine.disease_cause, medicine, Antioxidant, medicine.medical_treatment, Glutathione peroxidase, chemistry.chemical_classification, Article, Parkinson’s disease, QD241-441
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publication . Article . Other literature type . 2017

Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells

Dengke Bao; Jingkai Wang; Xiaobin Pang; Hongliang Liu;