publication . Article . 2010

Alteraciones en el reclutamiento y activación de proteínas Rab durante la infección micobacteriana

Diana Maria Castaño Monsalve; Mauricio Rojas López; Mauricio Rojas López; Diana Maria Castaño Monsalve;
Open Access Spanish; Castilian
  • Published: 30 Jun 2010
  • Publisher: BIOMÉDICA
Abstract
En el fagosoma, Mycobacterium spp. altera la activación y reclutamiento de diferentes proteínas "del gen Ras de cerebro de rata", comúnmente conocidas como Rab. En este manuscrito se revisa una serie de reportes que han demostrado que los fagosomas que contienen micobacterias tienen una expresión mayor y sostenida de Rab5, Rab11, Rab14 y Rab22a, y menor o ninguna expresión de Rab7, Rab9 y Rab6. Esto se correlaciona con aumento de la fusión de estos fagosomas con endosomas tempranos y de reciclaje, lo que les permite mantener ciertas características de compartimentos tempranos, permite que las bacterias obtengan acceso a nutrientes y previene la activación de mec...
Subjects
free text keywords: Ciencias Médicas y de la Salud, Medicina Clínica, Medicina General e Interna, tuberculosis, Mycobacterium tuberculosis, proteínas de unión a GTP rab, proteínas SNARE, fagosomas, endosomas., endosomas, rab GTP-binding proteins, SNARE proteins, phagosomes, endosomes, Medicine, R, Arctic medicine. Tropical medicine, RC955-962, General Biochemistry, Genetics and Molecular Biology, General Medicine, GTPase, Cell biology, Rab, RNA, Mycobacterium, biology.organism_classification, biology, Phagosome, Gene silencing, Mutant, Endosome
Related Organizations
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publication . Article . 2010

Alteraciones en el reclutamiento y activación de proteínas Rab durante la infección micobacteriana

Diana Maria Castaño Monsalve; Mauricio Rojas López; Mauricio Rojas López; Diana Maria Castaño Monsalve;