publication . Other literature type . Article . 2018

Exploiting immune cell metabolic machinery for functional HIV cure and the prevention of inflammaging

Clovis S. Palmer; Riya Palchaudhuri; Hassan Albargy; Mohamed Abdel-Mohsen; Suzanne M. Crowe;
  • Published: 30 Jan 2018
  • Publisher: F1000 Research Ltd
Abstract
<ns4:p>An emerging paradigm in immunology suggests that metabolic reprogramming and immune cell activation and functions are intricately linked. Viral infections, such as HIV infection, as well as cancer force immune cells to undergo major metabolic challenges. Cells must divert energy resources in order to mount an effective immune response. However, the fact that immune cells adopt specific metabolic programs to provide host defense against intracellular pathogens and how this metabolic shift impacts immune cell functions and the natural course of diseases have only recently been appreciated. A clearer insight into how these processes are inter-related will af...
Subjects
free text keywords: Immune Cell Activation, Immunology, Cancer, medicine.disease, medicine, Intracellular parasite, Energy resources, Cell, medicine.anatomical_structure, Immune system, Inflammation, medicine.symptom, business.industry, business, Reprogramming, Review, Articles, HIV Infection & AIDS: Basic Science, Immune Response, Immunity to Infections, immune cells, metabolic shift, HIV, immunometabolism, R, Science, Q
Related Organizations
Funded by
NIH| Exploring Cell-free Glycomic Interactions in HIV-associated Neurological Disorders
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R21NS106970-02
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
,
NIH| University of Washington Center for AIDS Research
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P30AI027757-18
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Role of Host Glycosylation in the Galectin-9-Mediated Reversal of HIV Latency
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 7R21AI129636-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
90 references, page 1 of 6

1 Pearce EL Poffenberger MC Chang C: Fueling immunity: insights into metabolism and lymphocyte function.Science.2013;342(6155):1242454. 10.1126/science.1242454 24115444 [OpenAIRE] [PubMed] [DOI]

2 Palmer CS Ostrowski M Balderson B: Glucose metabolism regulates T cell activation, differentiation, and functions.Front Immunol.2015;6:1. 10.3389/fimmu.2015.00001 25657648 [OpenAIRE] [PubMed] [DOI]

3 Palmer CS Duette GA Wagner MCE: Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection.FEBS Lett.2017;591(20):3319–32. 10.1002/1873-3468.12843 28892135 [OpenAIRE] [PubMed] [DOI]

4 Palmer CS Ostrowski M Gouillou M: Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection.AIDS.2014;28(3):297–309. 10.1097/QAD.0000000000000128 24335483 [OpenAIRE] [PubMed] [DOI]

5 Planas D Zhang Y Monteiro P: HIV-1 selectively targets gut-homing CCR6 +CD4 + T cells via mTOR-dependent mechanisms.JCI Insight.2017;2(15): pii: 93230. 10.1172/jci.insight.93230 28768913 [OpenAIRE] [PubMed] [DOI]

6 Lachmandas E Beigier-Bompadre M Cheng SC: Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.Eur J Immunol.2016;46(11):2574–86. 10.1002/eji.201546259 27624090 [OpenAIRE] [PubMed] [DOI]

7 Lönnberg T Svensson V James KR: Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves T h 1/T fh fate bifurcation in malaria.Sci Immunol.2017;2(9): pii: eaal2192. 10.1126/sciimmunol.aal2192 28345074 [OpenAIRE] [PubMed] [DOI]

8 Fisicaro P Barili V Montanini B: Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B.Nat Med.2017;23(3):327–36. 10.1038/nm.4275 28165481 [OpenAIRE] [PubMed] [DOI]

9 Palmer CS Anzinger JJ Zhou J: Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV + subjects.J Immunol.2014;193(11):5595–603. 10.4049/jimmunol.1303092 25367121 [OpenAIRE] [PubMed] [DOI]

10 Butterfield TR Hanna DB Kaplan RC: Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular disease.AIDS.2017;31(2):199–205. 10.1097/QAD.0000000000001320 27835618 [OpenAIRE] [PubMed] [DOI]

11 Hegedus A Kavanagh Williamson M Huthoff H: HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells.Retrovirology.2014;11:98. 10.1186/s12977-014-0098-4 25421745 [OpenAIRE] [PubMed] [DOI]

12 Cretenet G Clerc I Matias M: Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions.Sci Rep.2016;6: 24129. 10.1038/srep24129 27067254 [OpenAIRE] [PubMed] [DOI]

13 Lamers SL Rose R Maidji E: HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads.J Virol.2016;90(20):8968–83. 10.1128/JVI.00674-16 27466426 [OpenAIRE] [PubMed] [DOI]

14 Cribbs SK Lennox J Caliendo AM: Healthy HIV-1-infected individuals on highly active antiretroviral therapy harbor HIV-1 in their alveolar macrophages.AIDS Res Hum Retroviruses.2015;31(1):64–70. 10.1089/AID.2014.0133 25134819 [OpenAIRE] [PubMed] [DOI]

15 Asahchop EL Meziane O Mamik MK: Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.Retrovirology.2017;14(1):47. 10.1186/s12977-017-0370-5 29037245 [OpenAIRE] [PubMed] [DOI]

90 references, page 1 of 6
Abstract
<ns4:p>An emerging paradigm in immunology suggests that metabolic reprogramming and immune cell activation and functions are intricately linked. Viral infections, such as HIV infection, as well as cancer force immune cells to undergo major metabolic challenges. Cells must divert energy resources in order to mount an effective immune response. However, the fact that immune cells adopt specific metabolic programs to provide host defense against intracellular pathogens and how this metabolic shift impacts immune cell functions and the natural course of diseases have only recently been appreciated. A clearer insight into how these processes are inter-related will af...
Subjects
free text keywords: Immune Cell Activation, Immunology, Cancer, medicine.disease, medicine, Intracellular parasite, Energy resources, Cell, medicine.anatomical_structure, Immune system, Inflammation, medicine.symptom, business.industry, business, Reprogramming, Review, Articles, HIV Infection & AIDS: Basic Science, Immune Response, Immunity to Infections, immune cells, metabolic shift, HIV, immunometabolism, R, Science, Q
Related Organizations
Funded by
NIH| Exploring Cell-free Glycomic Interactions in HIV-associated Neurological Disorders
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R21NS106970-02
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
,
NIH| University of Washington Center for AIDS Research
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P30AI027757-18
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Role of Host Glycosylation in the Galectin-9-Mediated Reversal of HIV Latency
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 7R21AI129636-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
90 references, page 1 of 6

1 Pearce EL Poffenberger MC Chang C: Fueling immunity: insights into metabolism and lymphocyte function.Science.2013;342(6155):1242454. 10.1126/science.1242454 24115444 [OpenAIRE] [PubMed] [DOI]

2 Palmer CS Ostrowski M Balderson B: Glucose metabolism regulates T cell activation, differentiation, and functions.Front Immunol.2015;6:1. 10.3389/fimmu.2015.00001 25657648 [OpenAIRE] [PubMed] [DOI]

3 Palmer CS Duette GA Wagner MCE: Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection.FEBS Lett.2017;591(20):3319–32. 10.1002/1873-3468.12843 28892135 [OpenAIRE] [PubMed] [DOI]

4 Palmer CS Ostrowski M Gouillou M: Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection.AIDS.2014;28(3):297–309. 10.1097/QAD.0000000000000128 24335483 [OpenAIRE] [PubMed] [DOI]

5 Planas D Zhang Y Monteiro P: HIV-1 selectively targets gut-homing CCR6 +CD4 + T cells via mTOR-dependent mechanisms.JCI Insight.2017;2(15): pii: 93230. 10.1172/jci.insight.93230 28768913 [OpenAIRE] [PubMed] [DOI]

6 Lachmandas E Beigier-Bompadre M Cheng SC: Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.Eur J Immunol.2016;46(11):2574–86. 10.1002/eji.201546259 27624090 [OpenAIRE] [PubMed] [DOI]

7 Lönnberg T Svensson V James KR: Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves T h 1/T fh fate bifurcation in malaria.Sci Immunol.2017;2(9): pii: eaal2192. 10.1126/sciimmunol.aal2192 28345074 [OpenAIRE] [PubMed] [DOI]

8 Fisicaro P Barili V Montanini B: Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B.Nat Med.2017;23(3):327–36. 10.1038/nm.4275 28165481 [OpenAIRE] [PubMed] [DOI]

9 Palmer CS Anzinger JJ Zhou J: Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV + subjects.J Immunol.2014;193(11):5595–603. 10.4049/jimmunol.1303092 25367121 [OpenAIRE] [PubMed] [DOI]

10 Butterfield TR Hanna DB Kaplan RC: Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular disease.AIDS.2017;31(2):199–205. 10.1097/QAD.0000000000001320 27835618 [OpenAIRE] [PubMed] [DOI]

11 Hegedus A Kavanagh Williamson M Huthoff H: HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells.Retrovirology.2014;11:98. 10.1186/s12977-014-0098-4 25421745 [OpenAIRE] [PubMed] [DOI]

12 Cretenet G Clerc I Matias M: Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions.Sci Rep.2016;6: 24129. 10.1038/srep24129 27067254 [OpenAIRE] [PubMed] [DOI]

13 Lamers SL Rose R Maidji E: HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads.J Virol.2016;90(20):8968–83. 10.1128/JVI.00674-16 27466426 [OpenAIRE] [PubMed] [DOI]

14 Cribbs SK Lennox J Caliendo AM: Healthy HIV-1-infected individuals on highly active antiretroviral therapy harbor HIV-1 in their alveolar macrophages.AIDS Res Hum Retroviruses.2015;31(1):64–70. 10.1089/AID.2014.0133 25134819 [OpenAIRE] [PubMed] [DOI]

15 Asahchop EL Meziane O Mamik MK: Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.Retrovirology.2017;14(1):47. 10.1186/s12977-017-0370-5 29037245 [OpenAIRE] [PubMed] [DOI]

90 references, page 1 of 6
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publication . Other literature type . Article . 2018

Exploiting immune cell metabolic machinery for functional HIV cure and the prevention of inflammaging

Clovis S. Palmer; Riya Palchaudhuri; Hassan Albargy; Mohamed Abdel-Mohsen; Suzanne M. Crowe;