publication . Article . 2016

Establishment of a rat model of early-stage liver failure and Th17/Treg imbalance

LI Dong; LU Zhonghua; GAN Jianhe;
Open Access Chinese
  • Published: 01 May 2016 Journal: Linchuang Gandanbing Zazhi (issn: 1001-5256, eissn: 1001-5256, Copyright policy)
  • Publisher: Editorial Department of Journal of Clinical Hepatology
Abstract
ObjectiveTo investigate the methods for establishing a rat model of early-stage liver failure and the changes in Th17, Treg, and Th17/Treg after dexamethasone and thymosin interventions. MethodsA total of 64 rats were randomly divided into carbon tetrachloride (CCl4) group and endotoxin [lipopolysaccharide (LPS)]/D-galactosamine (D-GalN) combination group to establish the rat model of early-stage liver failure. The activities of the rats and changes in liver function and whole blood Th17 and Treg were observed to evaluate the effectiveness of the rat model. Dexamethasone and thymosin were used for intervention and related effects were observed. The t-test was us...
Subjects
free text keywords: Diseases of the digestive system. Gastroenterology, RC799-869
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