publication . Article . 2010

The role of surface microtopography in the modulation of osteoblast differentiation.

Hayes, J. S.; Kahn, I. M.; Archer, C. W.; Robert Richards;
Abstract
The osteoinductive and conductive capabilities of commercially pure titanium and its alloys is well documented, as is their ability to provide long-term stability for permanent implantable devices. Fracture fixation in paediatric and trauma patients generally requires transient fixation after which the implant becomes redundant and requires removal. Removal can be complicated due to excessive bony over-growth which is encouraged by the standard micro-rough implant surface. We have shown in vivo that removal related morbidity can be significantly reduced with surface polishing, a technique which reduces the micro-roughness of clinically available materials. Howev...
Subjects
free text keywords: titanium, gene expression, surface modification, osteoblast differentiation, cell morphology, Surgery, RD1-811, Diseases of the musculoskeletal system, RC925-935
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Dalby MJ (2005) Topographically induced direct cell [OpenAIRE]

Acknowledgements mechanotransduction. Med Eng Phys 27: 730-742.

Dalby MJ, Andar A, Nag A, Affrossman S, Tare R, The authors wish to thank Synthes, Bettlach, Switzerland, McFarlane S, Oreffo RO (2008) Genomic expression of for kindly providing the materials used in this study, and mesenchymal stem cells to altered nanoscale topographies. Dr V Frauchiger (Robert Mathis Foundation, Bettlach, J R Soc Interface 5: 1055-1065. Switzerland) for XPS measurements. Degasne I, Basle M.F, Demais V, Hure G, Lesourd M,

Grolleau B, Mercier L, Chappard D (1999) Effects of

Alzahrani AG, Behairy YM, Alhossan MH, Arab FS, (SaOs-2) on titanium surfaces. Calcif Tissue Int 64: 499- AlammariAA(2003) Removal of internal fixation devices 507. in pediatric patients. Saudi Med J 24: 254-255. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G

Arcelli D, PalmieriA, Pezzetti F, Brunelli G, Zollino I, (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast Carinci F (2007) Genetic effects of titanium surface on differentiation. Cell 89: 747-754. osteoblasts: A meta-analysis. J Oral Sci 49: 299-309. Forgacs G (1995) On the possible role of cytoskeletal

Balloni S, Calvi EM, Damiani F, Bistoni G, Calvitti M, filamentous networks in intracellular signaling: an Locci P, Becchetti E, Marinucci L (2009) Effects of approach based on percolation. J Cell Sci 108: 2131-2143. titanium surface roughness on mesenchymal stem cell Gerber I, ap Gwynn I (2001) Influence of cell isolation, commitment and differentiation signaling. Int J Oral cell culture density, and cell nutrition on differentiation of Maxillofac Implants 24: 627-635. rat calvarial osteoblast-like cells in vitro. Eur Cell Mater

Berry CC, Dalby MJ, Oreffo RO, McCloy D, 2: 10-20. Affrosman S (2006) The interaction of human bone Getzenberg RH (1994) Nuclear matrix and the marrow cells with nanotopographical features in three regulation of gene expression: tissue specificity. J Cell dimensional constructs. J Biomed Mater Res A79: 431- Biochem 55: 22-31. 439.

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publication . Article . 2010

The role of surface microtopography in the modulation of osteoblast differentiation.

Hayes, J. S.; Kahn, I. M.; Archer, C. W.; Robert Richards;