publication . Article . 2014

Cytoglobin expression in oxidative stressed liver during systemic chronic normobaric hypoxia and relation with HIF-1α

Sri W.A. Jusman; Febriana C. Iswanti; Franciscus D. Suyatna; Frans Ferdinal; Septelia I. Wanandi; Mohamad Sadikin;
Open Access English
  • Published: 15 Oct 2014 Journal: Medical Journal of Indonesia (issn: 0853-1773, eissn: 2252-8083, Copyright policy)
  • Publisher: Faculty of Medicine Universitas Indonesia
Abstract
<p><strong>Background:</strong> Liver is sensitive against hypoxia and hypoxia will stabilize HIF-1α. At the same time, hypoxia will produce reactive oxygen species (ROS) which can be scavenged by Cygb. The purpose of our study is to know, if normobaric hypoxia can induce Cygb expression and its association with HIF-1α stabilization.</p><p><strong>Methods:</strong> This is an experimental study using 28 male Sprague-Dawley rats, 150-200 g weight. Rats are divided into 7 groups: control group and treatment groups that are kept in hypoxic chamber (10% O<sub>2</sub>: 90% N<sub>2</sub>) for 6 hours, 1, 2, 3, 7 and 14 days. All rats are euthanized after treatment and...
Subjects
free text keywords: cytoglobin, HIF-1α, liver, oxidative stress, systemic chronic normobaric hypoxia, Medicine (General), R5-920, General Medicine, Biochemistry, Surgery, medicine.medical_specialty, medicine, Oxidative phosphorylation, Liver tissue, Hypoxia (medical), medicine.symptom, Diabetes mellitus, medicine.disease, Messenger RNA, Reactive oxygen species, chemistry.chemical_classification, chemistry, Internal medicine, medicine.disease_cause, Endocrinology, Biology
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publication . Article . 2014

Cytoglobin expression in oxidative stressed liver during systemic chronic normobaric hypoxia and relation with HIF-1α

Sri W.A. Jusman; Febriana C. Iswanti; Franciscus D. Suyatna; Frans Ferdinal; Septelia I. Wanandi; Mohamad Sadikin;