publication . Article . 2017

Symptomatic Congenital Cytomegalovirus Infection in Children of Seropositive Women

Ines Mack; Marie-Anne Burckhardt; Marie-Anne Burckhardt; Ulrich Heininger; Friederike Prüfer; Sven Schulzke; Sven Wellmann;
Open Access English
  • Published: 09 Jun 2017 Journal: Frontiers in Pediatrics (issn: 2296-2360, Copyright policy)
  • Publisher: Frontiers Media S.A.
Cytomegalovirus (CMV) is the most frequent congenital virus infection worldwide. The risk of congenital CMV (cCMV) transmission is highest in seronegative women who acquire primary CMV infection during pregnancy. A growing body of evidence indicates that secondary CMV infections in pregnant women with preconceptual immunity (either through reactivation of latent virus or re-infection with a new strain of CMV) contribute to a much greater proportion of symptomatic cCMV than was previously thought. Here, we describe a case of symptomatic cCMV infection in the newborn of a woman with proven immunity prior to pregnancy. Diagnosis was confirmed by CMV PCR from amniot...
free text keywords: cytomegalovirus infections, pregnancy, hearing loss, calcification, blueberry muffin, magnetic resonance imaging, Pediatrics, RJ1-570, Case Report, neuroimaging, Jaundice, medicine.symptom, medicine, medicine.disease, Sensorineural hearing loss, business.industry, business, Hepatosplenomegaly, medicine.medical_specialty, Ganciclovir, medicine.drug, Immunology, Seroconversion, Intensive care medicine, Valganciclovir
23 references, page 1 of 2

1 Sharland M Cytomegalovirus. In: Mike S Karina B Andrew C Ron D Graha m D Ronald de G, editors. Manual of Childhood Infections/The Blue Book. Oxford, UK: Oxford University Press (2016). p. 507–12, 945 and 965.

2 Leruez-Ville M Ville Y. Fetal cytomegalovirus infection. Best Pract Res Clin Obstet Gynaecol (2017) 38:97–107.10.1016/j.bpobgyn.2016.10.005 27923540 [OpenAIRE] [PubMed] [DOI]

3 Naing ZW Scott GM Shand A Hamilton ST van Zuylen WJ Basha J Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention. Aust N Z J Obstet Gynaecol (2016) 56(1):9–18.10.1111/ajo.12408 26391432 [OpenAIRE] [PubMed] [DOI]

4 Kimberlin DW Jester PM Sánchez PJ Ahmed A Arav-Boger R Michaels MG Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med (2015) 372(10):933–43.10.1056/NEJMoa1404599 25738669 [OpenAIRE] [PubMed] [DOI]

5 James SH Kimberlin DW. Advances in the prevention and treatment of congenital cytomegalovirus infection. Curr Opin Pediatr (2016) 28(1):81–5.10.1097/MOP.0000000000000305 26709686 [OpenAIRE] [PubMed] [DOI]

6 De Vries JJ van Zwet EW Dekker FW Kroes AC Verkerk PH Vossen AC. The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. Rev Med Virol (2013) 23(4):241–9.10.1002/rmv.1744 23559569 [OpenAIRE] [PubMed] [DOI]

7 Wang C Zhang X Bialek S Cannon MJ. Attribution of congenital cytomegalovirus infection to primary versus non-primary maternal infection. Clin Infect Dis (2011) 52(2):e11–3.10.1093/cid/ciq085 21288834 [OpenAIRE] [PubMed] [DOI]

8 Boppana SB Rivera LB Fowler KB Mach M Britt WJ. Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med (2001) 344(18):1366–71.10.1056/NEJM200105033441804 11333993 [PubMed] [DOI]

9 Smiechura M Strużycka M Konopka W. Congenital and acquired cytomegalovirus infection and hearing evaluation in children. Otolaryngol Pol (2014) 68(6):303–7.10.1016/j.otpol.2014.04.003 25308607 [OpenAIRE] [PubMed] [DOI]

10 Cannie MM Devlieger R Leyder M Claus F Leus A De Catte L Congenital cytomegalovirus infection: contribution and best timing of prenatal MR imaging. Eur Radiol (2016) 26(10):3760–9.10.1007/s00330-015-4187-0 26984434 [OpenAIRE] [PubMed] [DOI]

11 Jarvis D Mooney C Cohen J Papaioannou D Bradburn M Sutton A A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities in utero. Eur Radiol (2016) 27:2367–80.10.1007/s00330-016-4563-4 27655301 [OpenAIRE] [PubMed] [DOI]

12 Kimberlin DW Lin CY Sanchez PJ Demmler GJ Dankner W Shelton M Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr (2003) 143(1):16–25.10.1016/S0022-3476(03)00192-6 12915819 [OpenAIRE] [PubMed] [DOI]

13 Oliver SE Cloud GA Sanchez PJ Demmler GJ Dankner W Shelton M Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system. J Clin Virol (2009) 46(Suppl 4):S22–6.10.1016/j.jcv.2009.08.012 19766534 [OpenAIRE] [PubMed] [DOI]

14 Lackner A Acham A Alborno T Moser M Engele H Raggam RB Effect on hearing of ganciclovir therapy for asymptomatic congenital cytomegalovirus infection: four to 10 year follow up. J Laryngol Otol (2009) 123(4):391–6.10.1017/S0022215108003162 18588736 [PubMed] [DOI]

15 Imamura T Suzutani T Ogawa H Asano K Nomoto M Matsui T Oral valganciclovir treatment for congenital cytomegalovirus infection. Pediatr Int (2011) 53(2):249–52.10.1111/j.1442-200X.2010.03217.x 21501311 [OpenAIRE] [PubMed] [DOI]

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publication . Article . 2017

Symptomatic Congenital Cytomegalovirus Infection in Children of Seropositive Women

Ines Mack; Marie-Anne Burckhardt; Marie-Anne Burckhardt; Ulrich Heininger; Friederike Prüfer; Sven Schulzke; Sven Wellmann;