Thyrotoxic periodic paralysis

Article English OPEN
Balakrishnan, Rojith Karanode ; Chandran, Suresh Rama ; Thirumalnesan, Geetha ; Doraisamy, Nedumaran (2011)
  • Publisher: Medknow Publications
  • Journal: Indian Journal of Endocrinology and Metabolism, volume 15, issue Suppl2, pages S147-S149 (issn: 2230-8210, eissn: 2230-9500)
  • Related identifiers: doi: 10.4103/2230-8210.83360, pmc: PMC3169856
  • Subject: Diseases of the digestive system. Gastroenterology | oral potassium | hypokalemia | Acute flaccid periodic paralysis | RC648-665 | RC799-869 | thyrotoxicosis | genetic predisposition | Case Report | Diseases of the endocrine glands. Clinical endocrinology
    mesheuropmc: nervous system diseases

This article aims at highlighting the importance of suspecting thyrotoxicosis in cases of recurrent periodic flaccid paralysis; especially in Asian men to facilitate early diagnosis of the former condition. A case report of a 28 year old male patient with recurrent periodic flaccid paralysis has been presented. Hypokalemia secondary to thyrotoxicosis was diagnosed as the cause of the paralysis. The patient was given oral potassium intervention over 24 hours. The patient showed complete recovery after the medical intervention and was discharged after 24 hours with no residual paralysis. Thyrotoxic periodic paralysis (TPP) is a complication of thyrotoxicosis, more common amongst males in Asia. It presents as acute flaccid paralysis in a case of hyperthyroidism with associated hypokalemia. The features of thyrotoxicosis may be subtle or absent. Thus, in cases of recurrent or acute flaccid muscle paralysis, it is important to consider thyrotoxicosis as one of the possible causes, and take measures accordingly.
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