Negative Effect of Ellagic Acid on Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Cancer Cells

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Khalid N. M. Abdelazeem; Yogesh Singh; Florian Lang; Madhuri S. Salker;
  • Publisher: Cell Physiol Biochem Press GmbH & Co KG
  • Journal: Cellular Physiology and Biochemistry (issn: 1015-8987, eissn: 1421-9778)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1159/000475655
  • Subject: Glycolysis | Cytosolic pH regulation | Na+/H+ exchanger | NHE1 | Tumor cells | Physiology | QP1-981 | Biochemistry | QD415-436

Background/Aims: Key properties of tumor cells include enhanced glycolytic flux with excessive consumption of glucose and formation of lactate. As glycolysis is highly sensitive to cytosolic pH, maintenance of glycolysis requires export of H+ ions, which is in part acco... View more
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