publication . Article . 2018

Increasing Power by Sharing Information from Genetic Background and Treatment in Clustering of Gene Expression Time Series

Sura Zaki Alrashid; Muhammad Arifur Rahman; Nabeel H Al-Aaraji; Neil D Lawrence; Paul R Heath;
Open Access Arabic
  • Published: 02 Feb 2018 Journal: Journal of University of Babylon (issn: 1992-0652, eissn: 2312-8135, Copyright policy)
  • Publisher: University of Babylon
Abstract
<jats:p>Clustering of gene expression time series gives insight into which genes may be co-regulated, allowing us to discern the activity of pathways in a given microarray experiment. Of particular interest is how a given group of genes varies with different conditions or genetic background. This paper develops
a new clustering method that allows each cluster to be parameterised according to whether the behaviour of the genes across conditions is correlated or anti-correlated. By specifying correlation between such genes,more information is gain within the cluster about how the genes interrelate. Amyotrophic lateral sclerosis (ALS) is an irreversible neurodegene...
Subjects
free text keywords: Gaussian process, Kernel, Hierarchical clusters, Amyotrophic lateral sclerosis, Education, L, Science, Q, Computational biology, Gene expression, Cluster analysis, Biology
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publication . Article . 2018

Increasing Power by Sharing Information from Genetic Background and Treatment in Clustering of Gene Expression Time Series

Sura Zaki Alrashid; Muhammad Arifur Rahman; Nabeel H Al-Aaraji; Neil D Lawrence; Paul R Heath;