publication . Article . 2018

Streptococcus agalactiae Inhibits Candida albicans Hyphal Development and Diminishes Host Vaginal Mucosal TH17 Response.

Xiao-Yu Yu; Fei Fu; Wen-Na Kong; Qian-Kun Xuan; Dong-Hua Wen; Xiao-Qing Chen; Yong-Ming He; Li-Hua He; Jian Guo; Ai-Ping Zhou; ...
Open Access English
  • Published: 01 Feb 2018 Journal: Frontiers in Microbiology (issn: 1664-302X, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Streptococcus agalactiae and Candida albicans often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with S. agalactiae significantly attenuated the hyphal development of C. albicans, and that EFG1-Hwp1 signal pathway of C. albicans was involved in this process. In a mouse model of vulvovaginal candidiasis (VVC), the fungal burden and the levels of pro-inflammatory cytokines, IL-1, IL-6, TNF-α, and IFN-γ showed a dramatic increase on co-infection with S. agalactiae, while the expression...
Subjects
free text keywords: C. albicans, S. agalactiae, hyphal development, vaginal mucosa, TH17 response, Microbiology, QR1-502, Original Research, Microbiology (medical), Genital tract, Hypha, Candida albicans, biology.organism_classification, biology, Vulvovaginal Candidiasis, Immunity, Streptococcus agalactiae, medicine.disease_cause, medicine, Colonization, Corpus albicans
Related Organizations
50 references, page 1 of 4

Andes D.Nett J.Oschel P.Albrecht R.Marchillo K.Pitula A. (2004). Development and characterization of an in vivo central venous catheter Candida albicans biofilm model. Infect. Immun. 72 6023–6031. 10.1128/IAI.72.10.6023-6031.2004 15385506 [OpenAIRE] [PubMed] [DOI]

Brand A.Barnes J. D.Mackenzie K. S.Odds F. C.Gow N. A. (2008). Cell wall glycans and soluble factors determine the interactions between the hyphae of Candida albicans and Pseudomonas aeruginosa. FEMS Microbiol. Lett. 287 48–55. 10.1111/j.1574-6968.2008.01301.x 18680523 [OpenAIRE] [PubMed] [DOI]

Calderone R. A. (2002). Candida and Candidiasis. Washington, DC: ASM Press.

Conti H. R.Shen F.Nayyar N.Stocum E.Sun J. N.Lindemann M. J. (2009). Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206 299–311. 10.1084/jem.20081463 19204111 [OpenAIRE] [PubMed] [DOI]

Cruz M. R.Graham C. E.Gagliano B. C.Lorenz M. C.Garsin D. A. (2013). Enterococcus faecalis inhibits hyphal morphogenesis and virulence of Candida albicans. Infect. Immun. 81 189–200. 10.1128/IAI.00914-12 23115035 [OpenAIRE] [PubMed] [DOI]

De Bernardis F.Lucciarini R.Boccanera M.Amantini C.Arancia S.Morrone S. (2006). Phenotypic and functional characterization of vaginal dendritic cells in a rat model of Candida albicans vaginitis. Infect. Immun. 74 4282–4294. 10.1128/IAI.01714-05 16790803 [OpenAIRE] [PubMed] [DOI]

Donders G.Bellen G.Rezeberga D. (2011). Aerobic vaginitis in pregnancy. BJOG 118 1163–1170. 10.1111/j.1471-0528.2011.03020.x 21668769 [OpenAIRE] [PubMed] [DOI]

Donders G. G.Van Calsteren K.Bellen G.Reybrouck R.Van den Bosch T.Riphagen I. (2009). Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. BJOG 116 1315–1324. 10.1111/j.1471-0528.2009.02237.x 19538417 [OpenAIRE] [PubMed] [DOI]

Donders G. G.Vereecken A.Bosmans E.Dekeersmaecker A.Salembier G.Spitz B. (2002). Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. BJOG 109 34–43. 10.1111/j.1471-0528.2002.00432.x 11845812 [OpenAIRE] [PubMed] [DOI]

Enjalbert B.Rachini A.Vediyappan G.Pietrella D.Spaccapelo R.Vecchiarelli A. (2009). A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections. Infect. Immun. 77 4847–4858. 10.1128/IAI.00223-09 19687206 [OpenAIRE] [PubMed] [DOI]

Fan Y.He H.Dong Y.Pan H. (2013). Hyphae-specific genes HGC1, ALS3, HWP1, and ECE1 and relevant signaling pathways in Candida albicans. Mycopathologia 176 329–335. 10.1007/s11046-013-9684-6 24002103 [OpenAIRE] [PubMed] [DOI]

Fidel P. L.Jr.Barousse M.Espinosa T.Ficarra M.Sturtevant J.Martin D. H. (2004). An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis. Infect. Immun. 72 2939–2946. 10.1128/IAI.72.5.2939-2946.2004 15102806 [OpenAIRE] [PubMed] [DOI]

Fidel P. L.Jr.Luo W.Steele C.Chabain J.Baker M.Wormley F.Jr. (1999). Analysis of vaginal cell populations during experimental vaginal candidiasis. Infect. Immun. 67 3135–3140.10338532 [OpenAIRE] [PubMed]

Fonzi W. A.Irwin M. Y. (1993). Isogenic strain construction and gene mapping in Candida albicans. Genetics 134 717–728. 8349105 [OpenAIRE] [PubMed]

Fourie R.Ells R.Swart C. W.Sebolai O. M.Albertyn J.Pohl C. H. (2016). Candida albicans and Pseudomonas aeruginosa interaction, with focus on the role of Eicosanoids. Front. Physiol. 7:64. 10.3389/fphys.2016.00064 26955357 [OpenAIRE] [PubMed] [DOI]

50 references, page 1 of 4
Abstract
Streptococcus agalactiae and Candida albicans often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with S. agalactiae significantly attenuated the hyphal development of C. albicans, and that EFG1-Hwp1 signal pathway of C. albicans was involved in this process. In a mouse model of vulvovaginal candidiasis (VVC), the fungal burden and the levels of pro-inflammatory cytokines, IL-1, IL-6, TNF-α, and IFN-γ showed a dramatic increase on co-infection with S. agalactiae, while the expression...
Subjects
free text keywords: C. albicans, S. agalactiae, hyphal development, vaginal mucosa, TH17 response, Microbiology, QR1-502, Original Research, Microbiology (medical), Genital tract, Hypha, Candida albicans, biology.organism_classification, biology, Vulvovaginal Candidiasis, Immunity, Streptococcus agalactiae, medicine.disease_cause, medicine, Colonization, Corpus albicans
Related Organizations
50 references, page 1 of 4

Andes D.Nett J.Oschel P.Albrecht R.Marchillo K.Pitula A. (2004). Development and characterization of an in vivo central venous catheter Candida albicans biofilm model. Infect. Immun. 72 6023–6031. 10.1128/IAI.72.10.6023-6031.2004 15385506 [OpenAIRE] [PubMed] [DOI]

Brand A.Barnes J. D.Mackenzie K. S.Odds F. C.Gow N. A. (2008). Cell wall glycans and soluble factors determine the interactions between the hyphae of Candida albicans and Pseudomonas aeruginosa. FEMS Microbiol. Lett. 287 48–55. 10.1111/j.1574-6968.2008.01301.x 18680523 [OpenAIRE] [PubMed] [DOI]

Calderone R. A. (2002). Candida and Candidiasis. Washington, DC: ASM Press.

Conti H. R.Shen F.Nayyar N.Stocum E.Sun J. N.Lindemann M. J. (2009). Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206 299–311. 10.1084/jem.20081463 19204111 [OpenAIRE] [PubMed] [DOI]

Cruz M. R.Graham C. E.Gagliano B. C.Lorenz M. C.Garsin D. A. (2013). Enterococcus faecalis inhibits hyphal morphogenesis and virulence of Candida albicans. Infect. Immun. 81 189–200. 10.1128/IAI.00914-12 23115035 [OpenAIRE] [PubMed] [DOI]

De Bernardis F.Lucciarini R.Boccanera M.Amantini C.Arancia S.Morrone S. (2006). Phenotypic and functional characterization of vaginal dendritic cells in a rat model of Candida albicans vaginitis. Infect. Immun. 74 4282–4294. 10.1128/IAI.01714-05 16790803 [OpenAIRE] [PubMed] [DOI]

Donders G.Bellen G.Rezeberga D. (2011). Aerobic vaginitis in pregnancy. BJOG 118 1163–1170. 10.1111/j.1471-0528.2011.03020.x 21668769 [OpenAIRE] [PubMed] [DOI]

Donders G. G.Van Calsteren K.Bellen G.Reybrouck R.Van den Bosch T.Riphagen I. (2009). Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. BJOG 116 1315–1324. 10.1111/j.1471-0528.2009.02237.x 19538417 [OpenAIRE] [PubMed] [DOI]

Donders G. G.Vereecken A.Bosmans E.Dekeersmaecker A.Salembier G.Spitz B. (2002). Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. BJOG 109 34–43. 10.1111/j.1471-0528.2002.00432.x 11845812 [OpenAIRE] [PubMed] [DOI]

Enjalbert B.Rachini A.Vediyappan G.Pietrella D.Spaccapelo R.Vecchiarelli A. (2009). A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections. Infect. Immun. 77 4847–4858. 10.1128/IAI.00223-09 19687206 [OpenAIRE] [PubMed] [DOI]

Fan Y.He H.Dong Y.Pan H. (2013). Hyphae-specific genes HGC1, ALS3, HWP1, and ECE1 and relevant signaling pathways in Candida albicans. Mycopathologia 176 329–335. 10.1007/s11046-013-9684-6 24002103 [OpenAIRE] [PubMed] [DOI]

Fidel P. L.Jr.Barousse M.Espinosa T.Ficarra M.Sturtevant J.Martin D. H. (2004). An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis. Infect. Immun. 72 2939–2946. 10.1128/IAI.72.5.2939-2946.2004 15102806 [OpenAIRE] [PubMed] [DOI]

Fidel P. L.Jr.Luo W.Steele C.Chabain J.Baker M.Wormley F.Jr. (1999). Analysis of vaginal cell populations during experimental vaginal candidiasis. Infect. Immun. 67 3135–3140.10338532 [OpenAIRE] [PubMed]

Fonzi W. A.Irwin M. Y. (1993). Isogenic strain construction and gene mapping in Candida albicans. Genetics 134 717–728. 8349105 [OpenAIRE] [PubMed]

Fourie R.Ells R.Swart C. W.Sebolai O. M.Albertyn J.Pohl C. H. (2016). Candida albicans and Pseudomonas aeruginosa interaction, with focus on the role of Eicosanoids. Front. Physiol. 7:64. 10.3389/fphys.2016.00064 26955357 [OpenAIRE] [PubMed] [DOI]

50 references, page 1 of 4
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publication . Article . 2018

Streptococcus agalactiae Inhibits Candida albicans Hyphal Development and Diminishes Host Vaginal Mucosal TH17 Response.

Xiao-Yu Yu; Fei Fu; Wen-Na Kong; Qian-Kun Xuan; Dong-Hua Wen; Xiao-Qing Chen; Yong-Ming He; Li-Hua He; Jian Guo; Ai-Ping Zhou; ...