publication . Article . 2018

Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements.

Jifeng Gu; Weijun Wu; Mengwei Huang; Fen Long; Xinhua Liu; Yizhun Zhu;
Open Access English
  • Published: 01 Apr 2018 Journal: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, volume 23, issue 4 (eissn: 1420-3049, Copyright policy)
  • Publisher: MDPI
A method for high-performance liquid chromatography coupled with linear ion trap quadrupole Orbitrap high-resolution mass spectrometry (HPLC-LTQ-Orbitrap MS) was developed and validated for the qualitative and quantitative assessment of Shejin-liyan Granule. According to the fragmentation mechanism and high-resolution MS data, 54 compounds, including fourteen isoflavones, eleven ligands, eight flavonoids, six physalins, six organic acids, four triterpenoid saponins, two xanthones, two alkaloids, and one licorice coumarin, were identified or tentatively characterized. In addition, ten of the representative compounds (matrine, galuteolin, tectoridin, iridin, arcti...
free text keywords: Article, Shejin-liyan Granule, HPLC-LTQ-Orbitrap MS, identification, quality assessment, QD241-441, Organic Chemistry
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