publication . Article . 2013

Arctigenin, a Potential Anti-Arrhythmic Agent, Inhibits Aconitine-Induced Arrhythmia by Regulating Multi-Ion Channels

Zhenying Zhao; Yongqiang Yin; Hong Wu; Min Jiang; Jianshi Lou; Gang Bai; Guo‘an Luo;
Open Access English
  • Published: 01 Nov 2013 Journal: Cellular Physiology and Biochemistry (issn: 1015-8987, eissn: 1421-9778, Copyright policy)
  • Publisher: Cell Physiol Biochem Press GmbH & Co KG
Abstract
e These authors contributed equally Abstract Background/Aims: Arctigenin possesses biological activities, but its underlying mechanisms at the cellular and ion channel levels are not completely understood. Therefore, the present study was designed to identify the anti-arrhythmia effect of arctigenin in vivo, as well as its cellular targets and mechanisms. Methods: A rat arrhythmia model was established via continuous aconitine infusion, and the onset times of ventricular premature contraction, ventricular tachycardia and death were recorded. The Action Potential Duration (APD), sodium current (I Na ), L-type calcium current (I Ca, L ) and transient outward potas...
Subjects
Medical Subject Headings: cardiovascular system
free text keywords: Arctigenin, Arrhythmia, Ion channel, Patch clamp, Aconitine, Physiology, QP1-981, Biochemistry, QD415-436, Sodium channel, chemistry.chemical_compound, chemistry, Potassium channel, Electrophysiology, Pharmacology, Myocyte, Anti-Arrhythmia Agents, Biology
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publication . Article . 2013

Arctigenin, a Potential Anti-Arrhythmic Agent, Inhibits Aconitine-Induced Arrhythmia by Regulating Multi-Ion Channels

Zhenying Zhao; Yongqiang Yin; Hong Wu; Min Jiang; Jianshi Lou; Gang Bai; Guo‘an Luo;