publication . Article . 2014

Molecular detection of AdeABC efflux pump genes in clinical isolates of Acinetobacter baumannii and their contribution in imipenem resistance

Ali Reza JaponiNejad; Masoomeh Sofian; Ehsanolah Ghaznavi-Rad;
Open Access English
  • Published: 01 Nov 2014 Journal: Iranian South Medical Journal (issn: 1735-4374, eissn: 1735-6954, Copyright policy)
  • Publisher: Bushehr University of Medical Sciences
Backgrand: Multi-drug resistance due to Acinetobacter baumannii strains has become a significant challenge. Efflux pump plays a vital role in the development of resistance in this bacteria. The aim of this study was to evaluate the frequency of the AdeABC efflux pump genes and its role in resistance to imipenem in clinical isolates of A.baumannii. Materials and methods: A total of 56 isolates of A.baumannii were collected from different clinical specimens of Valiasr hospital in the Arak –Iran and all isolates were identified by standard biochemical tests. The Antimicrobial susceptibility patterns were determined by disk diffusion method and minimum inhibit...
Medical Subject Headings: biochemical phenomena, metabolism, and nutritionpolycyclic compoundsbacterial infections and mycoses
free text keywords: Acinetobacter baumannii, AdeABC efflux pump, resistance to imipenem, Medicine (General), R5-920
Download from

23.Qi C, Malczynski M. Parker M, et al.

Characterization of genetic diversity of carbapenem-resistant Acinetobacter baumannii clinical strains collected from 2004 to 2007.

Journal of Clinical Microbiology(J Clin Microbiol) 2008;46:1106-9.

24.Gordon NC, Wareham DW. Multidrugresistant Acinetobacter baumannii: mechanisms of virulence and resistance. International journal of antimicrobial agents (Int J Antimicrob Agents)2010;35:219-26.

25.Vahdat K, Rezaee R, Gharibi O. Bacteriology of hospital-acquired infection and antibiotic resistance in a hospital university of Bushehr Port Fatemeh Zahra (s) in 2002-2003. ISMJ. 2005; 7(2) :135-140.

26.Zeki abbasi M, Bahtooie M, Vahdat K, Tavakolli M, Dalaki F. Antibiotic susceptibility of microorganisms of urinary tract infection in adult outpatients in Bushehr port. ISMJ. 2008; 10 (2) :153-158.

27.Japoni-Nejad A, Sofian M, van Belkum A, Ghaznavi-Rad E. Nosocomial Outbreak of Extensively Pan Drug-Resistant Acinetobacter baumannii in Tertiary Hospital in Central Part of Iran. Jundishapour journal of Microbilogy 2013;69(8): e9892

Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue