publication . Article . 2014

Molecular detection of AdeABC efflux pump genes in clinical isolates of Acinetobacter baumannii and their contribution in imipenem resistance

Ali Reza JaponiNejad; Masoomeh Sofian; Ehsanolah Ghaznavi-Rad;
Open Access English
  • Published: 01 Nov 2014 Journal: Iranian South Medical Journal (issn: 1735-4374, eissn: 1735-6954, Copyright policy)
  • Publisher: Bushehr University of Medical Sciences
Abstract
Backgrand: Multi-drug resistance due to Acinetobacter baumannii strains has become a significant challenge. Efflux pump plays a vital role in the development of resistance in this bacteria. The aim of this study was to evaluate the frequency of the AdeABC efflux pump genes and its role in resistance to imipenem in clinical isolates of A.baumannii. Materials and methods: A total of 56 isolates of A.baumannii were collected from different clinical specimens of Valiasr hospital in the Arak –Iran and all isolates were identified by standard biochemical tests. The Antimicrobial susceptibility patterns were determined by disk diffusion method and minimum inhibit...
Subjects
Medical Subject Headings: biochemical phenomena, metabolism, and nutritionpolycyclic compoundsbacterial infections and mycoses
free text keywords: Acinetobacter baumannii, AdeABC efflux pump, resistance to imipenem, Medicine (General), R5-920
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