publication . Article . 2017

Elevated Serum Cyclophilin B Levels Are Associated with the Prevalence and Severity of Metabolic Syndrome

Hang Zhang; Hang Zhang; Qin Fan; Qin Fan; Hongyang Xie; Hongyang Xie; Lin Lu; Lin Lu; Rong Tao; Fang Wang; ...
Open Access English
  • Published: 01 Dec 2017 Journal: Frontiers in Endocrinology (issn: 1664-2392, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
ObjectiveInflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation. We investigated the relationship between CypB and MetS in both humans and mice.MethodsSerum CypB levels were determined in 211 subjects with MetS and 292 subjects without MetS (non-MetS) (133 healthy controls and 159 high-risk subjects with one to two MetS components). Additionally, CypB expression in metabolic organs was examined in mice fed with high-fat diet (HFD) and genetically obese (ob/ob) mice.ResultsSerum...
Subjects
free text keywords: cyclophilin B, CD147, metabolic syndrome, inflammation, cardiovascular risk, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Original Research, Pathogenesis, medicine.disease, medicine, Biomarker (medicine), Systemic inflammation, medicine.symptom, Diabetes mellitus, Endocrinology, medicine.medical_specialty, Biology, Internal medicine, Oxidative stress, medicine.disease_cause
Related Organizations
36 references, page 1 of 3

1 Alberti KG Zimmet P Shaw J IDF Epidemiology Task Force Consensus Group The metabolic syndrome – a new worldwide definition. Lancet (2005) 366:1059–62.10.1016/S0140-6736(05)67402-8 16182882 [PubMed] [DOI]

2 Eckel RH Grundy SM Zimmet PZ. The metabolic syndrome. Lancet (2005) 365:1415–28.10.1016/S0140-6736(05)66378-7 15836891 [PubMed] [DOI]

3 Esposito K Chiodini P Colao A Lenzi A Giugliano D. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care (2012) 35:2402–11.10.2337/dc12-0336 23093685 [OpenAIRE] [PubMed] [DOI]

4 Xu Y Wang L He J Bi Y Li M Wang T Prevalence and control of diabetes in Chinese adults. JAMA (2013) 310:948–59.10.1001/jama.2013.168118 24002281 [OpenAIRE] [PubMed] [DOI]

5 Shirakawa K Yan X Shinmura K Endo J Kataoka M Katsumata Y Obesity accelerates T cell senescence in murine visceral adipose tissue. J Clin Invest (2016) 126:4626–39.10.1172/JCI88606 27820698 [OpenAIRE] [PubMed] [DOI]

6 O’Neill S Bohl M Gregersen S Hermansen K O’Driscoll L. Blood-based biomarkers for metabolic syndrome. Trends Endocrinol Metab (2016) 27:363–74.10.1016/j.tem.2016.03.012 27150849 [OpenAIRE] [PubMed] [DOI]

7 Brestoff JR Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell (2015) 161:146–60.10.1016/j.cell.2015.02.022 25815992 [OpenAIRE] [PubMed] [DOI]

8 Yurchenko V Constant S Eisenmesser E Bukrinsky M. Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics. Clin Exp Immunol (2010) 160:305–17.10.1111/j.1365-2249.2010.04115.x 20345978 [OpenAIRE] [PubMed] [DOI]

9 Cabral WA Perdivara I Weis M Terajima M Blissett AR Chang W Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta. PLoS Genet (2014) 10:e1004465.10.1371/journal.pgen.1004465 24968150 [OpenAIRE] [PubMed] [DOI]

10 Ishikawa Y Bachinger HP An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. J Biol Chem (2013) 288:31437–46.10.1074/jbc.M113.498063 24043621 [OpenAIRE] [PubMed] [DOI]

11 Bukrinsky M. Extracellular cyclophilins in health and disease. Biochim Biophys Acta (2015) 1850:2087–95.10.1016/j.bbagen.2014.11.013 25445705 [OpenAIRE] [PubMed] [DOI]

12 De Ceuninck F Allain F Caliez A Spik G Vanhoutte PM. High binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases: possible role as a proinflammatory mediator in arthritis. Arthritis Rheum (2003) 48:2197–206.10.1002/art.11099 12905473 [OpenAIRE] [PubMed] [DOI]

13 Fearon P Lonsdale-Eccles AA Ross OK Todd C Sinha A Allain F Keratinocyte secretion of cyclophilin B via the constitutive pathway is regulat ed through its cyclosporin-binding site. J Invest Dermatol (2011) 131:1085–94.10.1038/jid.2010.415 21270823 [OpenAIRE] [PubMed] [DOI]

14 Lackey DE Olefsky JM. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol (2016) 12:15–28.10.1038/nrendo.2015.189 26553134 [OpenAIRE] [PubMed] [DOI]

15 Ray P Rialon-Guevara KL Veras E Sullenger BA White RR. Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. J Clin Invest (2012) 122:1734–41.10.1172/JCI62385 22484812 [OpenAIRE] [PubMed] [DOI]

36 references, page 1 of 3
Abstract
ObjectiveInflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation. We investigated the relationship between CypB and MetS in both humans and mice.MethodsSerum CypB levels were determined in 211 subjects with MetS and 292 subjects without MetS (non-MetS) (133 healthy controls and 159 high-risk subjects with one to two MetS components). Additionally, CypB expression in metabolic organs was examined in mice fed with high-fat diet (HFD) and genetically obese (ob/ob) mice.ResultsSerum...
Subjects
free text keywords: cyclophilin B, CD147, metabolic syndrome, inflammation, cardiovascular risk, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Original Research, Pathogenesis, medicine.disease, medicine, Biomarker (medicine), Systemic inflammation, medicine.symptom, Diabetes mellitus, Endocrinology, medicine.medical_specialty, Biology, Internal medicine, Oxidative stress, medicine.disease_cause
Related Organizations
36 references, page 1 of 3

1 Alberti KG Zimmet P Shaw J IDF Epidemiology Task Force Consensus Group The metabolic syndrome – a new worldwide definition. Lancet (2005) 366:1059–62.10.1016/S0140-6736(05)67402-8 16182882 [PubMed] [DOI]

2 Eckel RH Grundy SM Zimmet PZ. The metabolic syndrome. Lancet (2005) 365:1415–28.10.1016/S0140-6736(05)66378-7 15836891 [PubMed] [DOI]

3 Esposito K Chiodini P Colao A Lenzi A Giugliano D. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care (2012) 35:2402–11.10.2337/dc12-0336 23093685 [OpenAIRE] [PubMed] [DOI]

4 Xu Y Wang L He J Bi Y Li M Wang T Prevalence and control of diabetes in Chinese adults. JAMA (2013) 310:948–59.10.1001/jama.2013.168118 24002281 [OpenAIRE] [PubMed] [DOI]

5 Shirakawa K Yan X Shinmura K Endo J Kataoka M Katsumata Y Obesity accelerates T cell senescence in murine visceral adipose tissue. J Clin Invest (2016) 126:4626–39.10.1172/JCI88606 27820698 [OpenAIRE] [PubMed] [DOI]

6 O’Neill S Bohl M Gregersen S Hermansen K O’Driscoll L. Blood-based biomarkers for metabolic syndrome. Trends Endocrinol Metab (2016) 27:363–74.10.1016/j.tem.2016.03.012 27150849 [OpenAIRE] [PubMed] [DOI]

7 Brestoff JR Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell (2015) 161:146–60.10.1016/j.cell.2015.02.022 25815992 [OpenAIRE] [PubMed] [DOI]

8 Yurchenko V Constant S Eisenmesser E Bukrinsky M. Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics. Clin Exp Immunol (2010) 160:305–17.10.1111/j.1365-2249.2010.04115.x 20345978 [OpenAIRE] [PubMed] [DOI]

9 Cabral WA Perdivara I Weis M Terajima M Blissett AR Chang W Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta. PLoS Genet (2014) 10:e1004465.10.1371/journal.pgen.1004465 24968150 [OpenAIRE] [PubMed] [DOI]

10 Ishikawa Y Bachinger HP An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. J Biol Chem (2013) 288:31437–46.10.1074/jbc.M113.498063 24043621 [OpenAIRE] [PubMed] [DOI]

11 Bukrinsky M. Extracellular cyclophilins in health and disease. Biochim Biophys Acta (2015) 1850:2087–95.10.1016/j.bbagen.2014.11.013 25445705 [OpenAIRE] [PubMed] [DOI]

12 De Ceuninck F Allain F Caliez A Spik G Vanhoutte PM. High binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases: possible role as a proinflammatory mediator in arthritis. Arthritis Rheum (2003) 48:2197–206.10.1002/art.11099 12905473 [OpenAIRE] [PubMed] [DOI]

13 Fearon P Lonsdale-Eccles AA Ross OK Todd C Sinha A Allain F Keratinocyte secretion of cyclophilin B via the constitutive pathway is regulat ed through its cyclosporin-binding site. J Invest Dermatol (2011) 131:1085–94.10.1038/jid.2010.415 21270823 [OpenAIRE] [PubMed] [DOI]

14 Lackey DE Olefsky JM. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol (2016) 12:15–28.10.1038/nrendo.2015.189 26553134 [OpenAIRE] [PubMed] [DOI]

15 Ray P Rialon-Guevara KL Veras E Sullenger BA White RR. Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. J Clin Invest (2012) 122:1734–41.10.1172/JCI62385 22484812 [OpenAIRE] [PubMed] [DOI]

36 references, page 1 of 3
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publication . Article . 2017

Elevated Serum Cyclophilin B Levels Are Associated with the Prevalence and Severity of Metabolic Syndrome

Hang Zhang; Hang Zhang; Qin Fan; Qin Fan; Hongyang Xie; Hongyang Xie; Lin Lu; Lin Lu; Rong Tao; Fang Wang; ...