A landscape of therapeutic cooperativity in KRAS mutant cancers reveals principles for controlling tumor evolution

Article, Other literature type English OPEN
Grace R. Anderson; Peter S. Winter; Kevin H. Lin; Daniel P. Nussbaum; Merve Cakir; Elizabeth M. Stein; Ryan S. Soderquist; Lorin Crawford; Jim C. Leeds; Rachel Newcomb; Priya Stepp; Catherine Yip; Suzanne E. Wardell; Jennifer P. Tingley; Moiez Ali; Mengmeng Xu; Meagan Ryan; Shannon J. McCall; Autumn J. McRee; Christopher M. Counter; Channing J. Der; Kris C. Wood;

Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize therapeutic responses are unclear. Using CRISPR/Cas9, we systematically mapped the ... View more
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