publication . Article . 2018

Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models

Md. Josim Uddin; A. S. M. Ali Reza; Md. Abdullah-Al-Mamun; Mohammad S. H. Kabir; Mst. Samima Nasrin; Sharmin Akhter; Md. Saiful Islam Arman; Md. Atiar Rahman;
Open Access
  • Published: 01 Apr 2018 Journal: Frontiers in Pharmacology, volume 9 (eissn: 1663-9812, Copyright policy)
  • Publisher: Frontiers Media SA
Abstract
Anisomeles indica (L.) kuntze is widely used in folk medicine against various disorders including allergy, sores, inflammation, and fever. This research investigated the antinociceptive, anxiolytic and sedative effects of A. indica methanol extract. The antinociceptive activity was assessed with the acetic acid-induced writhing test and formalin-induced flicking test while sedative effects with open field and hole cross tests and anxiolytic effects with elevated plus maze (EPM) and thiopental-induced sleeping time tests were assayed. Computer aided (pass prediction, docking) analyses were undertaken to find out the best-fit phytoconstituent of total fourteen iso...
Subjects
free text keywords: Pharmacology (medical), Pharmacology, Methanol, chemistry.chemical_compound, chemistry, Open field, Diazepam, medicine.drug, medicine, Nociception, business.industry, business, Elevated plus maze, Anisomeles indica, Anxiolytic, medicine.drug_class, Licking, Original Research, writhing test, central pain, peripheral pain, neuropharmacology, Therapeutics. Pharmacology, RM1-950
67 references, page 1 of 5

Adzu B.Amos S.Kapu S.Gamaniel K. (2003). Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis. J. Ethnopharmacol. 84, 169–173. 10.1016/S0378-8741(02)00295-7 12648811 [OpenAIRE] [PubMed] [DOI]

Anil K. (2010). Ethnomedicine: A Source of Comp lementary Therapeutics. Kerala: Research Signpost.

Barria A.Derkach V.Soderling T. (1997). Identification of the Ca 2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. J. Biol. Chem. 272, 32727–32730. 9407043 [OpenAIRE] [PubMed]

Berman H. M.Battistuz T.Bhat T.Bluhm W. F.Bourne P. E.Burkhardt K.. (2002). The protein data bank. Acta Crystallogr. Sec. D Biol. Crystallogr.58, 899–907. 10.1107/S0907444902003451 12037327 [OpenAIRE] [PubMed] [DOI]

Bilici M.Ef e H.Köroglu M. A.Uydu H. A.Bekaroglu M.Deger O. (2001). Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J. Affect. Disord. 64, 43–51. 10.1016/S0165-0327(00)00199-3 11292519 [OpenAIRE] [PubMed] [DOI]

Burgos E.Pascual D.Martín M. I.Goicoechea C. (2010). Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests. Eur. J. Pain 14, 40–48. 10.1016/j.ejpain.2009.02.003 19318283 [OpenAIRE] [PubMed] [DOI]

Clavelou P.Dallel R.Orliaguet T.Woda A.Raboisson P. (1995). The orofacial formalin test in rats: effects of different formalin concentrations. Pain 62, 295–301. 10.1016/0304-3959(94)00273-H 8657429 [PubMed] [DOI]

Dallel R.Raboisson P.Clavelou P.Saade M.Woda A. (1995). Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin. Pain 61, 11–16. 10.1016/0304-3959(94)00212-W 7644233 [PubMed] [DOI]

Déciga-Campos M.Montiel-Ruiz R. M.Navarrete-Vázquez G.López-Muñoz F. J. (2007). Palmitic acid analogues exhibiting antinociceptive activity in mice. Proc. West. Pharmacol. Soc. 50, 75–77. 18605236 [OpenAIRE] [PubMed]

Dharmasiri M.Ratnasooriya W.Thabrew M. I. (2003). Water extract of leaves and stems of preflowering but not flowering plants of Anisomeles indica possesses analgesic and antihyperalgesic activities in rats. Pharm. Biol. 41, 37–44. 10.1076/phbi.41.1.37.14699 [OpenAIRE] [DOI]

Drapier D.Bentué-Ferrer D.Laviolle B.Millet B.Allain H.Bourin M.. (2007). Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze. Behav. Brain Res.176, 202–209. 10.1016/j.bbr.2006.10.002 17095104 [OpenAIRE] [PubMed] [DOI]

Ferreira S. H.Cunha F. Q.Lorenzetti B. B.Michelin M. A.Perretti M.Flower R. J.. (1997). Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. Braz. J. Pharmacol.121, 883–888. 10.1038/sj.bjp.0701211 9222544 [OpenAIRE] [PubMed] [DOI]

File S. E.Pellow S. (1985). The effects of PK 11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress. Pharmacol. Biochem. Behav. 23, 737–741. 10.1016/0091-3057(85)90064-4 3001779 [OpenAIRE] [PubMed] [DOI]

Fine P. G.Mahajan G.McPherson M. L. (2009). Long-acting opioid sandshort-acting opioids: appropriate use in chronic pain management. Pain Med. 10(Suppl. 2), S79–S88. 10.1111/j.1526-4637.2009.00666.x 19691687 [OpenAIRE] [PubMed] [DOI]

Fridlender M.Kapulnik Y.Koltai H. (2015). Plant derived substances with anti-cancer activity: from folklore to practice. Front. Plant Sci. 6:799. 10.3389/fpls.2015.00799 26483815 [OpenAIRE] [PubMed] [DOI]

67 references, page 1 of 5
Abstract
Anisomeles indica (L.) kuntze is widely used in folk medicine against various disorders including allergy, sores, inflammation, and fever. This research investigated the antinociceptive, anxiolytic and sedative effects of A. indica methanol extract. The antinociceptive activity was assessed with the acetic acid-induced writhing test and formalin-induced flicking test while sedative effects with open field and hole cross tests and anxiolytic effects with elevated plus maze (EPM) and thiopental-induced sleeping time tests were assayed. Computer aided (pass prediction, docking) analyses were undertaken to find out the best-fit phytoconstituent of total fourteen iso...
Subjects
free text keywords: Pharmacology (medical), Pharmacology, Methanol, chemistry.chemical_compound, chemistry, Open field, Diazepam, medicine.drug, medicine, Nociception, business.industry, business, Elevated plus maze, Anisomeles indica, Anxiolytic, medicine.drug_class, Licking, Original Research, writhing test, central pain, peripheral pain, neuropharmacology, Therapeutics. Pharmacology, RM1-950
67 references, page 1 of 5

Adzu B.Amos S.Kapu S.Gamaniel K. (2003). Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis. J. Ethnopharmacol. 84, 169–173. 10.1016/S0378-8741(02)00295-7 12648811 [OpenAIRE] [PubMed] [DOI]

Anil K. (2010). Ethnomedicine: A Source of Comp lementary Therapeutics. Kerala: Research Signpost.

Barria A.Derkach V.Soderling T. (1997). Identification of the Ca 2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. J. Biol. Chem. 272, 32727–32730. 9407043 [OpenAIRE] [PubMed]

Berman H. M.Battistuz T.Bhat T.Bluhm W. F.Bourne P. E.Burkhardt K.. (2002). The protein data bank. Acta Crystallogr. Sec. D Biol. Crystallogr.58, 899–907. 10.1107/S0907444902003451 12037327 [OpenAIRE] [PubMed] [DOI]

Bilici M.Ef e H.Köroglu M. A.Uydu H. A.Bekaroglu M.Deger O. (2001). Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J. Affect. Disord. 64, 43–51. 10.1016/S0165-0327(00)00199-3 11292519 [OpenAIRE] [PubMed] [DOI]

Burgos E.Pascual D.Martín M. I.Goicoechea C. (2010). Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests. Eur. J. Pain 14, 40–48. 10.1016/j.ejpain.2009.02.003 19318283 [OpenAIRE] [PubMed] [DOI]

Clavelou P.Dallel R.Orliaguet T.Woda A.Raboisson P. (1995). The orofacial formalin test in rats: effects of different formalin concentrations. Pain 62, 295–301. 10.1016/0304-3959(94)00273-H 8657429 [PubMed] [DOI]

Dallel R.Raboisson P.Clavelou P.Saade M.Woda A. (1995). Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin. Pain 61, 11–16. 10.1016/0304-3959(94)00212-W 7644233 [PubMed] [DOI]

Déciga-Campos M.Montiel-Ruiz R. M.Navarrete-Vázquez G.López-Muñoz F. J. (2007). Palmitic acid analogues exhibiting antinociceptive activity in mice. Proc. West. Pharmacol. Soc. 50, 75–77. 18605236 [OpenAIRE] [PubMed]

Dharmasiri M.Ratnasooriya W.Thabrew M. I. (2003). Water extract of leaves and stems of preflowering but not flowering plants of Anisomeles indica possesses analgesic and antihyperalgesic activities in rats. Pharm. Biol. 41, 37–44. 10.1076/phbi.41.1.37.14699 [OpenAIRE] [DOI]

Drapier D.Bentué-Ferrer D.Laviolle B.Millet B.Allain H.Bourin M.. (2007). Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze. Behav. Brain Res.176, 202–209. 10.1016/j.bbr.2006.10.002 17095104 [OpenAIRE] [PubMed] [DOI]

Ferreira S. H.Cunha F. Q.Lorenzetti B. B.Michelin M. A.Perretti M.Flower R. J.. (1997). Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. Braz. J. Pharmacol.121, 883–888. 10.1038/sj.bjp.0701211 9222544 [OpenAIRE] [PubMed] [DOI]

File S. E.Pellow S. (1985). The effects of PK 11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress. Pharmacol. Biochem. Behav. 23, 737–741. 10.1016/0091-3057(85)90064-4 3001779 [OpenAIRE] [PubMed] [DOI]

Fine P. G.Mahajan G.McPherson M. L. (2009). Long-acting opioid sandshort-acting opioids: appropriate use in chronic pain management. Pain Med. 10(Suppl. 2), S79–S88. 10.1111/j.1526-4637.2009.00666.x 19691687 [OpenAIRE] [PubMed] [DOI]

Fridlender M.Kapulnik Y.Koltai H. (2015). Plant derived substances with anti-cancer activity: from folklore to practice. Front. Plant Sci. 6:799. 10.3389/fpls.2015.00799 26483815 [OpenAIRE] [PubMed] [DOI]

67 references, page 1 of 5
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