publication . Article . Other literature type . 2018

Chromatin remodelling and epigenetic state regulation by non-coding RNAs in the diseased heart

F. De Majo; Martina Calore;
Open Access
  • Published: 01 Mar 2018 Journal: Non-coding RNA Research, volume 3, pages 20-28 (issn: 2468-0540, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Epigenetics refers to all the changes in phenotype and gene expression which are not due to alterations in the DNA sequence. These mechanisms have a pivotal role not only in the development but also in the maintenance during adulthood of a physiological phenotype of the heart. Because of the crucial role of epigenetic modifications, their alteration can lead to the arise of pathological conditions. Heart failure affects an estimated 23 million people worldwide and leads to substantial numbers of hospitalizations and health care costs: ischemic heart disease, hypertension, rheumatic fever and other valve diseases, cardiomyopathy, cardiopulmonary disease, congenit...
Persistent Identifiers
Subjects
free text keywords: Article, Cardiomyopathy, medicine.disease, medicine, Heart disease, Heart failure, Epigenetics, Bioinformatics, business.industry, business, Cardiopulmonary disease, Disease, Chromatin, Rheumatic fever, lcsh:Genetics, lcsh:QH426-470
Related Organizations
Funded by
EC| MIRAGE
Project
MIRAGE
MicroRNAs as therapeutic targets for ARVC.
  • Funder: European Commission (EC)
  • Project Code: 660440
  • Funding stream: H2020 | MSCA-IF-EF-ST
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