publication . Article . 2017

Differential Antifungal Activity of Human and Cryptococcal Melanins with Structural Discrepancies

Paula I. Rodas;
Open Access English
  • Published: 11 Jul 2017 Journal: Frontiers in Microbiology, volume 8 (eissn: 1664-302X, Copyright policy)
  • Publisher: Frontiers Media S.A.
  • Country: Germany
Abstract
Melanin is a pigment found in all biological kingdoms, and plays a key role in protection against ultraviolet radiation, oxidizing agents and ionizing radiation damage. Melanin exerts an antimicrobial activity against bacteria, fungi and parasites. We demonstrated an antifungal activity of synthetic and human melanin against Candida sp. The members of the Cryptococcus neoformans and C. gattii species complexes are capsulated yeasts, which cause cryptococcosis. For both species melanin is an important virulence factor. To evaluate if cryptococcal and human melanins have antifungal activity against Cryptococcus species they both were assayed for their antifungal p...
Subjects
Medical Subject Headings: integumentary systemsense organs
free text keywords: Microbiology, Original Research, melanin, antifungal activity, cryptococcosis, Cryptococcus spp., physical-chemical, QR1-502
Related Organizations
25 references, page 1 of 2

Alaluf S. Atkins D. Barrett K. Blount M. Carter N. Heath A. (2002). Ethnic variation in melanin content and composition in photoexposed and photoprotected human skin. Pigment Cell Res. 15 112–118. 10.1034/j.1600-0749.2002.1o071.x [OpenAIRE] [DOI]

Alaluf S. Heath A. Carter N. Atkins D. Mahalingam H. Barrett K. (2001). Variation in melanin content and composition in type V and VI photoexposed and photoprotected human skin: the dominant role of DHI. Pigment. Cell Res. 14 337–347. 10.1034/j.1600-0749.2001.140505.x [OpenAIRE] [DOI]

Arikan-Akdagli S. Barchiesi F. Bille J. Chryssanthou E. (2012). EUCAST DOCUMENTO DEFINITIVO 7.2.Revisión Método de Dilución en Caldo para la Determinación de las Concentraciones Mínimas Inhibitorias de Antifúngicos Para Levaduras. Available at: http://coesant-seimc.org/documents/Dil Caldo Levaduras.pdf

Banerjee A. Supakar S. Banerjee R. (2014). Melanin from the nitrogen-fixing Bacterium Azotobacter chroococcum: a spectroscopic characterization. PLoS ONE 9:e84574. 10.1371/journal.pone.0084574 [OpenAIRE] [DOI]

Casadevall A. Rosas A. L. Nosanchuk J. D. (2000). Melanin and virulence in Cryptococcus neoformans. Curr. Opin. Microbiol. 3 354–358. 10.1016/S1369-5274(00)00103-X [OpenAIRE] [DOI]

Chaskes S. Cammer M. Nieves E. Casadevall A. (2014). Pigment production on L-tryptophan medium by Cryptococcus gattii and Cryptococcus neoformans. PLoS ONE 9:e91901. 10.1371/journal.pone.0091901 [OpenAIRE] [DOI]

Costa T. G. Younger R. Poe C. Farmer P. J. Szpoganicz B. (201 2). Studies on synthetic and natural melanin and its affinity for Fe(III) ion. Bioinorg. Chem. Appl. 2012:712840. 10.1155/2012/712840 [OpenAIRE] [DOI]

Eisenman H. C. Casadevall A. (2012). Synthesis and assembly of fungal melanin. Appl. Microbiol. Biotechnol. 93 931–940. 10.1007/s00253-011-3777-2 [OpenAIRE] [DOI]

Eisenman H. C. Mues M. Weber S. E. Frases S. Chaskes S. Gerfen G. (2007). Cryptococcus neoformans laccase catalyses melanin synthesis from both D- and L-DOPA. Microbiology 153 3954–3962. 10.1099/mic.0.2007/011049-0 [OpenAIRE] [DOI]

Fuentes M. Hernández R. Gordillo D. Amaro J. Falconer M. A. Alburquenque C. (2014). Actividad antifúngica de melanina en cepas clínicas de Candida spp. Rev. Chilena Infectol. 31 28–33. 10.4067/S0716-10182014000100004 [OpenAIRE] [DOI]

Gullo F. P. Rossi S. A. Sardi J. de C. O. Teodoro V. L. I. Mendes-Giannini M. J. S. (2013). Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment. Eur. J. Clin. Microbiol. Infect. Dis. 32 1377–1391. 10.1007/s10096-013-1915-8 [OpenAIRE] [DOI]

Helan M. Rani S. Ramesh T. Subramanian J. Kalaiselvam M. (2013). Production and characterization of melanin pigment from halophilic black yeast Hortaea werneckii. Int. J. Pharma Res. Rev. 2 9–17.

Ito S. Wakamatsu K. (2003). Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review. Pigment Cell Res. 16 523–531. 10.1034/j.1600-0749.2003.00072.x [OpenAIRE] [DOI]

Kumar C. G. Mongolla P. Pombala S. Kamle A. Joseph J. (2011). Physicochemical characterization and antioxidant activity of melanin from a novel strain of Aspergillus bridgeri ICTF-201. Lett. Appl. Microbiol. 53 350–358. 10.1111/j.1472-765X.2011.03116.x [OpenAIRE] [DOI]

Liu Y. Kempf V. R. Nofsinger J. B. Weinert E. E. Rudnicki M. Wakamatsu K. (2003). Comparison of the structural and physical properties of human hair eumelanin following enzymatic or acid/base extraction. Pigment Cell Res. 16 355–365. 10.1034/j.1600-0749.2003.00059.x [OpenAIRE] [DOI]

25 references, page 1 of 2
Related research
Abstract
Melanin is a pigment found in all biological kingdoms, and plays a key role in protection against ultraviolet radiation, oxidizing agents and ionizing radiation damage. Melanin exerts an antimicrobial activity against bacteria, fungi and parasites. We demonstrated an antifungal activity of synthetic and human melanin against Candida sp. The members of the Cryptococcus neoformans and C. gattii species complexes are capsulated yeasts, which cause cryptococcosis. For both species melanin is an important virulence factor. To evaluate if cryptococcal and human melanins have antifungal activity against Cryptococcus species they both were assayed for their antifungal p...
Subjects
Medical Subject Headings: integumentary systemsense organs
free text keywords: Microbiology, Original Research, melanin, antifungal activity, cryptococcosis, Cryptococcus spp., physical-chemical, QR1-502
Related Organizations
25 references, page 1 of 2

Alaluf S. Atkins D. Barrett K. Blount M. Carter N. Heath A. (2002). Ethnic variation in melanin content and composition in photoexposed and photoprotected human skin. Pigment Cell Res. 15 112–118. 10.1034/j.1600-0749.2002.1o071.x [OpenAIRE] [DOI]

Alaluf S. Heath A. Carter N. Atkins D. Mahalingam H. Barrett K. (2001). Variation in melanin content and composition in type V and VI photoexposed and photoprotected human skin: the dominant role of DHI. Pigment. Cell Res. 14 337–347. 10.1034/j.1600-0749.2001.140505.x [OpenAIRE] [DOI]

Arikan-Akdagli S. Barchiesi F. Bille J. Chryssanthou E. (2012). EUCAST DOCUMENTO DEFINITIVO 7.2.Revisión Método de Dilución en Caldo para la Determinación de las Concentraciones Mínimas Inhibitorias de Antifúngicos Para Levaduras. Available at: http://coesant-seimc.org/documents/Dil Caldo Levaduras.pdf

Banerjee A. Supakar S. Banerjee R. (2014). Melanin from the nitrogen-fixing Bacterium Azotobacter chroococcum: a spectroscopic characterization. PLoS ONE 9:e84574. 10.1371/journal.pone.0084574 [OpenAIRE] [DOI]

Casadevall A. Rosas A. L. Nosanchuk J. D. (2000). Melanin and virulence in Cryptococcus neoformans. Curr. Opin. Microbiol. 3 354–358. 10.1016/S1369-5274(00)00103-X [OpenAIRE] [DOI]

Chaskes S. Cammer M. Nieves E. Casadevall A. (2014). Pigment production on L-tryptophan medium by Cryptococcus gattii and Cryptococcus neoformans. PLoS ONE 9:e91901. 10.1371/journal.pone.0091901 [OpenAIRE] [DOI]

Costa T. G. Younger R. Poe C. Farmer P. J. Szpoganicz B. (201 2). Studies on synthetic and natural melanin and its affinity for Fe(III) ion. Bioinorg. Chem. Appl. 2012:712840. 10.1155/2012/712840 [OpenAIRE] [DOI]

Eisenman H. C. Casadevall A. (2012). Synthesis and assembly of fungal melanin. Appl. Microbiol. Biotechnol. 93 931–940. 10.1007/s00253-011-3777-2 [OpenAIRE] [DOI]

Eisenman H. C. Mues M. Weber S. E. Frases S. Chaskes S. Gerfen G. (2007). Cryptococcus neoformans laccase catalyses melanin synthesis from both D- and L-DOPA. Microbiology 153 3954–3962. 10.1099/mic.0.2007/011049-0 [OpenAIRE] [DOI]

Fuentes M. Hernández R. Gordillo D. Amaro J. Falconer M. A. Alburquenque C. (2014). Actividad antifúngica de melanina en cepas clínicas de Candida spp. Rev. Chilena Infectol. 31 28–33. 10.4067/S0716-10182014000100004 [OpenAIRE] [DOI]

Gullo F. P. Rossi S. A. Sardi J. de C. O. Teodoro V. L. I. Mendes-Giannini M. J. S. (2013). Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment. Eur. J. Clin. Microbiol. Infect. Dis. 32 1377–1391. 10.1007/s10096-013-1915-8 [OpenAIRE] [DOI]

Helan M. Rani S. Ramesh T. Subramanian J. Kalaiselvam M. (2013). Production and characterization of melanin pigment from halophilic black yeast Hortaea werneckii. Int. J. Pharma Res. Rev. 2 9–17.

Ito S. Wakamatsu K. (2003). Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review. Pigment Cell Res. 16 523–531. 10.1034/j.1600-0749.2003.00072.x [OpenAIRE] [DOI]

Kumar C. G. Mongolla P. Pombala S. Kamle A. Joseph J. (2011). Physicochemical characterization and antioxidant activity of melanin from a novel strain of Aspergillus bridgeri ICTF-201. Lett. Appl. Microbiol. 53 350–358. 10.1111/j.1472-765X.2011.03116.x [OpenAIRE] [DOI]

Liu Y. Kempf V. R. Nofsinger J. B. Weinert E. E. Rudnicki M. Wakamatsu K. (2003). Comparison of the structural and physical properties of human hair eumelanin following enzymatic or acid/base extraction. Pigment Cell Res. 16 355–365. 10.1034/j.1600-0749.2003.00059.x [OpenAIRE] [DOI]

25 references, page 1 of 2
Related research
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue