publication . Article . 2018

Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital

Chatproedprai, Susheera; Wutticharoenwong, Vanvara; Tempark, Therdpong; Wananukul, Siriwan;
Open Access English
  • Published: 01 May 2018 Journal: Dermatology Research and Practice, volume 2,018 (issn: 1687-6105, eissn: 1687-6113, Copyright policy)
  • Publisher: Hindawi
Abstract
Aim. To determine the probable causative factors, clinical features, and treatment outcomes of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap in children. Methods. A 20-year database review of all children diagnosed with SJS/TEN/SJS-TEN overlap at the King Chulalongkorn Memorial Hospital, Thailand. Results. 36 patients (M : F, 16 : 20) with the mean age of 9.2±4.0 years were identified. There were 20 cases of SJS, 4 cases of SJS-TEN overlap, and 12 cases of TEN. Drugs were the leading cause for the diseases (72.3%); antiepileptics were the most common culprits (36.1%). Cutaneous morphology at presentation was morbilliform r...
Subjects
mesheuropmc: stomatognathic diseases
free text keywords: Dermatology, Research Article, RL1-803, Article Subject
39 references, page 1 of 3

Rzany, B., Mockenhaupt, M., Baur, S.. Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990-1992): Structure and results of a population-based registry. 1996; 49 (7): 769-773 [] [DOI]

Roujeau, J. C., Stern, R. S.. Severe adverse cutaneous reactions to drugs. 1994; 331 (19): 1272-1285 [] [DOI]

Dilokthornsakul, P., Sawangjit, R., Inprasong, C.. Healthcare utilization and cost of Stevens-Johnson syndrome and toxic epidermal necrolysis management in Thailand. 2016; 62 (2): 109-114 [OpenAIRE] [] [DOI]

Gerull, R., Nelle, M., Schaible, T.. Toxic epidermal necrolysis and Stevens-Johnson syndrome: A review. 2011; 39 (6): 1521-1532 [] [DOI]

Harr, T., French, L. E.. Toxic epidermal necrolysis and Stevens-Johnson syndrome. 2010; 5 (1, article no. 39) [OpenAIRE] [] [DOI]

Yang, C.-W., Cho, Y.-T., Chen, K.-L., Chen, Y.-C., Song, H.-L., Chu, C.-Y.. Long-term sequelae of stevens-johnson syndrome/toxic epidermal necrolysis. 2016; 96 (4): 525-529 [] [DOI]

Yamane, Y., Matsukura, S., Watanabe, Y.. Retrospective analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in 87 Japanese patients - Treatment and outcome. 2016; 65 (1): 74-81 [OpenAIRE] [] [DOI]

Wang, L., Mei, X.-L.. Retrospective analysis of stevens-johnson syndrome and toxic epidermal necrolysis in 88 Chinese patients. 2017; 130 (9): 1062-1068 [OpenAIRE] [] [DOI]

Thammakumpee, J., Yongsiri, S.. Characteristics of toxic epidermal necrolysis and stevens-johnson syndrome: A 5-year retrospective study. 2013; 96 (4): 399-406 []

Miliszewski, M. A., Kirchhof, M. G., Sikora, S., Papp, A., Dutz, J. P.. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Analysis of Triggers and Implications for Improving Prevention. 2016; 129 (11): 1221-1225 [] [DOI]

Kim, H.-I., Kim, S.-W., Park, G.-Y.. Causes and treatment outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in 82 adult patients. 2012; 27 (2): 203-210 [OpenAIRE] [] [DOI]

Haber, J., Hopman, W., Gomez, M., Cartotto, R.. Late outcomes in adult survivors of toxic epidermal necrolysis after treatment in a burn center. 2005; 26 (1): 33-41 [] [DOI]

Gerdts, B., Vloemans, A. F. P. M., Kreis, R. W.. Toxic epidermal necrolysis; 15.years'experience in a Dutch burns centre. 2007; 21 (6): 781-788 [] [DOI]

Gravante, G., Delogu, D., Marianetti, M., Trombetta, M., Esposito, G., Montone, A.. Toxic epidermal necrolysis and Steven Johnson syndrome: 11-years experience and outcome. 2007; 11 (2): 119-127 []

Tagami, H., Iwatsuki, K.. Elevated serum amylase in toxic epidermal necrolysis. 1986; 115 (2): 250-250 [] [DOI]

39 references, page 1 of 3
Abstract
Aim. To determine the probable causative factors, clinical features, and treatment outcomes of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap in children. Methods. A 20-year database review of all children diagnosed with SJS/TEN/SJS-TEN overlap at the King Chulalongkorn Memorial Hospital, Thailand. Results. 36 patients (M : F, 16 : 20) with the mean age of 9.2±4.0 years were identified. There were 20 cases of SJS, 4 cases of SJS-TEN overlap, and 12 cases of TEN. Drugs were the leading cause for the diseases (72.3%); antiepileptics were the most common culprits (36.1%). Cutaneous morphology at presentation was morbilliform r...
Subjects
mesheuropmc: stomatognathic diseases
free text keywords: Dermatology, Research Article, RL1-803, Article Subject
39 references, page 1 of 3

Rzany, B., Mockenhaupt, M., Baur, S.. Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990-1992): Structure and results of a population-based registry. 1996; 49 (7): 769-773 [] [DOI]

Roujeau, J. C., Stern, R. S.. Severe adverse cutaneous reactions to drugs. 1994; 331 (19): 1272-1285 [] [DOI]

Dilokthornsakul, P., Sawangjit, R., Inprasong, C.. Healthcare utilization and cost of Stevens-Johnson syndrome and toxic epidermal necrolysis management in Thailand. 2016; 62 (2): 109-114 [OpenAIRE] [] [DOI]

Gerull, R., Nelle, M., Schaible, T.. Toxic epidermal necrolysis and Stevens-Johnson syndrome: A review. 2011; 39 (6): 1521-1532 [] [DOI]

Harr, T., French, L. E.. Toxic epidermal necrolysis and Stevens-Johnson syndrome. 2010; 5 (1, article no. 39) [OpenAIRE] [] [DOI]

Yang, C.-W., Cho, Y.-T., Chen, K.-L., Chen, Y.-C., Song, H.-L., Chu, C.-Y.. Long-term sequelae of stevens-johnson syndrome/toxic epidermal necrolysis. 2016; 96 (4): 525-529 [] [DOI]

Yamane, Y., Matsukura, S., Watanabe, Y.. Retrospective analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in 87 Japanese patients - Treatment and outcome. 2016; 65 (1): 74-81 [OpenAIRE] [] [DOI]

Wang, L., Mei, X.-L.. Retrospective analysis of stevens-johnson syndrome and toxic epidermal necrolysis in 88 Chinese patients. 2017; 130 (9): 1062-1068 [OpenAIRE] [] [DOI]

Thammakumpee, J., Yongsiri, S.. Characteristics of toxic epidermal necrolysis and stevens-johnson syndrome: A 5-year retrospective study. 2013; 96 (4): 399-406 []

Miliszewski, M. A., Kirchhof, M. G., Sikora, S., Papp, A., Dutz, J. P.. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Analysis of Triggers and Implications for Improving Prevention. 2016; 129 (11): 1221-1225 [] [DOI]

Kim, H.-I., Kim, S.-W., Park, G.-Y.. Causes and treatment outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in 82 adult patients. 2012; 27 (2): 203-210 [OpenAIRE] [] [DOI]

Haber, J., Hopman, W., Gomez, M., Cartotto, R.. Late outcomes in adult survivors of toxic epidermal necrolysis after treatment in a burn center. 2005; 26 (1): 33-41 [] [DOI]

Gerdts, B., Vloemans, A. F. P. M., Kreis, R. W.. Toxic epidermal necrolysis; 15.years'experience in a Dutch burns centre. 2007; 21 (6): 781-788 [] [DOI]

Gravante, G., Delogu, D., Marianetti, M., Trombetta, M., Esposito, G., Montone, A.. Toxic epidermal necrolysis and Steven Johnson syndrome: 11-years experience and outcome. 2007; 11 (2): 119-127 []

Tagami, H., Iwatsuki, K.. Elevated serum amylase in toxic epidermal necrolysis. 1986; 115 (2): 250-250 [] [DOI]

39 references, page 1 of 3
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publication . Article . 2018

Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital

Chatproedprai, Susheera; Wutticharoenwong, Vanvara; Tempark, Therdpong; Wananukul, Siriwan;