Molecular docking and molecular dynamics simulation studies on Thermus thermophilus leucyl-tRNA synthetase complexed with different amino acids and pre-transfer editing substrates

Article English OPEN
Rayevsky A. V.; Tukalo M. A.;
(2016)
  • Publisher: Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine
  • Journal: Biopolymers and Cell (issn: 0233-7657, eissn: 1993-6842)
  • Related identifiers: doi: 10.7124/bc.00090E
  • Subject: leucyl-tRNAsynthetase | editing | amino acids | aminoacyl-adenylate | molecular docking | MD simulations | Biology (General) | QH301-705.5 | Genetics | QH426-470

Aim. To investigate the structural bases for the amino acid selectivity of the Thermus thermophilus leucyl-tRNA synthetase (LeuRSTT) aminoacylation site and to disclose the binding pattern of pre-transfer editing substrates. Methods. Eight amino acids proposed as semi-c... View more
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