Molecular docking and molecular dynamics simulation studies on Thermus thermophilus leucyl-tRNA synthetase complexed with different amino acids and pre-transfer editing substrates

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Rayevsky A. V.; Tukalo M. A.;
  • Publisher: Інститут молекулярної біології і генетики НАН України
  • Journal: issn: 0233-7657, eissn: 1993-6842
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.7124/bc.00090E
  • Subject: leucyl-tRNAsynthetase | QH426-470 | molecular docking | Genetics | MD simulations | amino acids | Bioinformatics | aminoacyl-adenylate | Biology (General) | editing | QH301-705.5

Aim. To investigate the structural bases for the amino acid selectivity of the Thermus thermophilus leucyl-tRNA synthetase (LeuRSTT) aminoacylation site and to disclose the binding pattern of pre-transfer editing substrates. Methods. Eight amino acids proposed as semi-c... View more