publication . Article . 2012

First Combined In Vivo X-Ray Tomography and High- Resolution Molecular Electron Paramagnetic Resonance (EPR) Imaging of the Mouse Knee Joint Taking into Account the Disappearance Kinetics of the EPR Probe

Bézière, Nicolas; Decroos, Christophe; Mkhitaryan, Karen; Kish, Elizabeth; RICHARD, Frédéric,; Bigot-Marchand, Stéphanie; Durand, Sylvain; Cloppet, Florence; Chauvet, Caroline; Corvol, Marie-Thérèse; ...
Open Access
  • Published: 01 Jun 2012 Journal: Molecular Imaging, volume 11, page 7290.2011.00042 (issn: 1536-0121, eissn: 1536-0121, Copyright policy)
  • Publisher: SAGE Publications
  • Country: France
Abstract
International audience; Although laboratory data clearly suggest a role for oxidants (dioxygen and free radicals derived from dioxygen) in the pathogenesis of many age-related and degenerative diseases (such as arthrosis and arthritis), methods to image such species in vivo are still very limited. This methodological problem limits physiopathologic studies about the role of those species in vivo, the effects of their regulation using various drugs, and the evaluation of their levels for diagnosis of degenerative diseases. In vivo electron paramagnetic resonance (EPR) imaging and spectroscopy are unique, noninvasive methods used to specifically detect and quantif...
Subjects
Medical Subject Headings: inorganic chemicals
free text keywords: Biotechnology, Molecular Medicine, Radiology Nuclear Medicine and imaging, Condensed Matter Physics, Biomedical Engineering, Electron paramagnetic resonance, law.invention, law, Tomography, X-ray, Chemistry, In vivo, Nuclear magnetic resonance, Analytical chemistry, Kinetics, Anatomic Location, Knee Joint, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Biology (General), QH301-705.5, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2012

First Combined In Vivo X-Ray Tomography and High- Resolution Molecular Electron Paramagnetic Resonance (EPR) Imaging of the Mouse Knee Joint Taking into Account the Disappearance Kinetics of the EPR Probe

Bézière, Nicolas; Decroos, Christophe; Mkhitaryan, Karen; Kish, Elizabeth; RICHARD, Frédéric,; Bigot-Marchand, Stéphanie; Durand, Sylvain; Cloppet, Florence; Chauvet, Caroline; Corvol, Marie-Thérèse; ...