publication . Article . Other literature type . 2015

The power of using functional fMRI on small rodents to study brain pharmacology and disease

Jonckers, Elisabeth; Shah, Disha; Hamaide, Julie; Verhoye, Marleen; Van der Linden, Annemie;
Open Access English
  • Published: 21 Oct 2015 Journal: Frontiers in Pharmacology, volume 6 (issn: 1663-9812, Copyright policy)
  • Publisher: Frontiers Media S.A.
  • Country: Belgium
Abstract: Functional magnetic resonance imaging (fMRI) is an excellent tool to study the effect of pharmacological modulations on brain function in a non-invasive and longitudinal manner. We introduce several blood oxygenation level dependent (BOLD) fMRI techniques, including resting state (rsfMRI), stimulus-evoked (st-fMRI), and pharmacological MRI (phMRI). Respectively, these techniques permit the assessment of functional connectivity during rest as well as brain activation triggered by sensory stimulation and/or a pharmacological challenge. The first part of this review describes the physiological basis of BOLD fMRI and the hemodynamic response on which the M...
Medical Subject Headings: nervous system
free text keywords: Biology, Pharmacology. Therapy, Human medicine, Pharmacology, fMRI, rsfMRI, phMRI, BOLD, rodents, functional MRI, Therapeutics. Pharmacology, RM1-950, Review, Pharmacology (medical), Neural activity, Neural substrate, Haemodynamic response, Sensory stimulation therapy, Medicine, business.industry, business, Resting state fMRI, Disease, EEG-fMRI, Functional magnetic resonance imaging, medicine.diagnostic_test
Related Organizations
Funded by
Molecular Imaging of Brain Pathophysiology
  • Funder: European Commission (EC)
  • Project Code: 612360
  • Funding stream: FP7 | SP3 | PEOPLE
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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