publication . Article . 2007

Ketogenic diet and astrocyte/neuron metabolic interactions

Joseph Vamecq; Pierre Maurois; Pierre Bac; Bernadette Delplanque; Nicole Pages;
Open Access English
  • Published: 01 May 2007 Journal: Oléagineux, Corps gras, Lipides, volume 14, issue 3, pages 208-213 (issn: 1258-8210, Copyright policy)
  • Publisher: EDP Sciences
The ketogenic diet is an anticonvulsant diet enriched in fat. It provides the body with a minimal protein requirement and a restricted carbohydrate supply, the vast majority of calories (more than 80-90%) being given by fat. Though anticonvulsant activity of ketogenic diet has been well documented by a large number of experimental and clinical studies, underlying mechanisms still remain partially unclear. Astrocyte-neuron interactions, among which metabolic shuttles, may influence synaptic activity and hence anticonvulsant protection. The astrocyte-neuron metabolic shuttles may be themselves influenced by the availability in energetic substrates such as hydrates...
Persistent Identifiers
free text keywords: ketogenic diet, epilepsy, astrocyte/neuron shuttle, glucose, lactate, ketone bodies, Food Science, Biochemistry, lcsh:Oils, fats, and waxes, lcsh:TP670-699, Biology, Neuroprotection, Ketosis, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, Glycolysis, Anticonvulsant, medicine.medical_treatment, Internal medicine, Glutamine, Astrocyte, medicine.anatomical_structure
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