publication . Article . 2007

Role of Peripheral Alpha2 Adrenergic Receptors in Tonic Pain During Different Stages of Estrous Cycle in Rats

AR Abyazi Shelmani; M Taherianfard;
Open Access Persian
  • Published: 01 Dec 2007 Journal: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd (issn: 2228-5741, eissn: 2228-5733, Copyright policy)
  • Publisher: Shahid Sadoughi University of Medical Sciences
Abstract
Introduction: Estrogen and progesterone are supposed to modify pain sensitivity. However, the actual role of each of these steroid hormones in this respect is not well known. Plasma concentrations of these hormones show variation during estrous cycle. The role of alpha2 receptors in tonic pain has been pointed out. The aim of the present study was to investigate the agonist and antagonist effect of alpha2 adrenergic receptors on tonic pain sensitivity during all stages of estrous cycle in female rats. Methods: Xylasine as alpha2 agonist and yohimbin as alpha2 antagonist were used via intraperitoneal route (IP). Adult rats weighing 180-200 grams were used. Animal...
Subjects
free text keywords: Xylasine, Yohimbine, Formalin Test, Estrous cycle, Rats, Medicine (General), R5-920
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