Choline Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition

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May, Thaddaeus; Klatt, Kevin C.; Smith, Jacob; Castro, Eumenia; Manary, Mark; Caudill, Marie A.; Jahoor, Farook; Fiorotto, Marta L.;
  • Publisher: MDPI AG
  • Journal: Nutrients,volume 10,issue 5 (issn: 2072-6643, eissn: 2072-6643)
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  • Related identifiers: doi: 10.3390/nu10050653, pmc: PMC5986532
  • Subject: TX341-641 | Article | hepatic steatosis | fatty liver disease | trimethylamine N-oxide (TMAO) | one carbon metabolism | Nutrition. Foods and food supply | malnutrition | choline | methionine | methylation | kwashiorkor | betaine
    mesheuropmc: cardiovascular system

Hepatic steatosis is a hallmark feature of kwashiorkor malnutrition. However, the pathogenesis of hepatic steatosis in kwashiorkor is uncertain. Our objective was to develop a mouse model of childhood undernutrition in order to test the hypothesis that feeding a maize v... View more
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