Randomized controlled trial on the effects of legumes on cardiovascular risk factors in women with abdominal obesity

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Abdolrasoul Safaeiyan ; Bahram Pourghassem-Gargari ; Rasoul Zarrin ; Javid Fereidooni ; Mohammad Alizadeh (2015)
  • Publisher: Vesnu Publications
  • Journal: ARYA Atherosclerosis, volume 11, issue 2, pages 117-125 (issn: 1735-3955, eissn: 2251-6638)
  • Related identifiers: pmc: PMC4568196
  • Subject: Original Article | Cardiovascular Disease | RC666-701 | Caloric Restriction | Legume | Diseases of the circulatory (Cardiovascular) system | Central Obesity | Premenopause | Legume, Cardiovascular Disease, Caloric Restriction, Central Obesity, Premenopause

<div><div><p class="abstract"><strong>BACKGROUND:</strong> The effect of legume-based hypocaloric diet on cardiovascular disease (CVD) risk factors in women is unclear. This study provides an opportunity to find effects of high-legume diet on CVD risk factors in women who consumed high legumes at baseline.</p> <p class="abstract"><strong>METHODS:</strong> This randomized controlled trial was undertaken in 34 premenopausal women with central obesity. After 2 weeks of a run-in period on an isocaloric diet, subjects were randomly assigned into two groups: (1) hypocaloric diet enriched with legumes (HDEL) (n = 17) (two servings per day) and (2) hypocaloric diet without legumes (HDWL) (n = 17) for 6 weeks. The following variables were assessed before intervention, 3, and 6 weeks after it: Waist to hip ratio (WHR), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-sensitive-C-reactive protein (hs-CRP), total antioxidant capacity (TAC), nitric oxides (NO<sub>x</sub>), and Malondialdehyde (MDA).</p> <p class="abstract"><strong>RESULTS:</strong><strong> </strong>Both hypocaloric diets reduced hs-CRP in 3 weeks and returned it to basal values after 6 weeks (P<em> </em>= 0.004). HDWL significantly reduced WHR [P<em> </em>= 0.010 (3.2%)] and increased TC [P &lt; 0.001 (6.3%)]. Despite the significant effect of HDEL on increasing TAC in 3 weeks <br /> [P = 0.050 (4%)], the level of TAC remained the same in 6 weeks. None of the diets had any significant effects on NO<sub>x</sub> and MDA.</p> <p class="abstract"><strong>CONCLUSION:</strong> The study indicated that beneficial effects of legumes on TC, LDL-C, and hs-CRP were achieved by three servings per week, and consuming more amounts of these products had no more advantages.</p> <p class="abstract">&nbsp;</p></div><p class="abstract">&nbsp;</p></div>
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