Traditional wireless positioning technology has low accuracy, and UWB positioning technology can achieve centimeter-level high-precision positioning to meet the accuracy requirements of the fully mechanized working face positioning systems. However, the existing researches ignore the impact of position change of the base station installed on the hydraulic support on the positioning effect. In order to solve the above problems, laser ranging technology is applied to the mine environment and a positioning system of fully mechanized working face based on UWB and laser ranging is designed. The positioning base station is installed on the hydraulic support, and the position of the base station changes when the position of the hydraulic support changes. The mine intrinsically safe laser ranging sensor is used to measure the distance between the positioning base stations. The external antenna of the positioning base station transmits fixed-power UWB wireless signals. The positioning base station communicates with the positioning identification card worn on the personnel or installed on the equipment, and determines the positioning information of the moving target through the time-of-flight ranging method. The positioning base station uploads the positioning information data to the ground data center through the mine ring network. The system test is carried out on the E2308 working face of Gaohe Coal Mine, and the result show that the positioning accuracy of the system reaches 0.193 m and the positioning accuracy is high. Moreover, the system base station position calibration accuracy is about 0.011 m, which solves the problem of base station position calibration effectively.