The goal is to search for patterns of changes that have occurred with the indicators of occupational morbidity in the population of Kuzbass and the Russian Federation for the period 2012-2021. Material and methods. A descriptive study was conducted using data from the Federal State Statistics Service (Rosstat) published in the statistical collection «Health in Russia» and statistical materials «Morbidity of the population of Kuzbass» for 2012-2021, state reports «On the state of sanitary and epidemiological well-being of the population of Kuzbass in 2021» and «On the state of sanitary and epidemiological welfare of the population in the Russian Federation in 2020». Results. The state of health of the population is an integral indicator of the well-being of the region. The high level of occupational morbidity of the working population indicates the impact of adverse production factors on the health status of the region's population. One of the preventive measures aimed at maintaining the health of the working population, identifying and preventing general somatic and occupational diseases are preliminary and periodic medical examinations of workers. In 2021, periodic medical examinations of employees were organized in 2,330 organizations. In total, 277,598 workers (including 107,426 women) were subject to periodic medical examinations on the territory of Kuzbass in 2021, 270,119 workers were examined (including 104,667 women). Coverage of periodic medical examinations (examinations) amounted to 97.3 % (2020 – 97.7 %). During periodic medical examinations in 2021, 421 (79.43 %) and 109 (20.57 %) preliminary diagnoses of an occupational disease were established.