publication . Article . Other literature type . 2017

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

Cristina M. Dorobantu; Leen Delang; Hilde M. van der Schaar; Vesa M. Olkkonen; Lucian Albulescu; Bishyajit Kumar Biswas; Johan Neyts; Joëlle Bigay; Frank J. M. van Kuppeveld; Marion Weber-Boyvat; ...
Open Access English
  • Published: 01 Apr 2017 Journal: Antiviral Research, volume 140, page 37 (issn: 0166-3542, Copyright policy)
  • Country: Belgium
Abstract
The genus Enterovirus (e.g. poliovirus, coxsackievirus, rhinovirus) of the Picornaviridae family of positive-strand RNA viruses includes many important pathogens linked to a range of acute and chronic diseases for which no approved antiviral therapy is available. Targeting a step in the life cycle that is highly conserved provides an attractive strategy for developing broad-range inhibitors of enterovirus infection. A step that is currently explored as a target for the development of antivirals is the formation of replication organelles, which support replication of the viral genome. To build replication organelles, enteroviruses rewire cellular machinery and hi...
Subjects
Medical Subject Headings: viruses
free text keywords: Enterovirus, Replication, OSBP, TTP-8307, Antiviral, Pharmacology, Virology, medicine.disease_cause, medicine, Coxsackievirus, biology.organism_classification, biology, Virus, Poliovirus, Genetics, Picornavirus, Oxysterol-binding protein, Picornaviridae
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