LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

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Susanto, Olivia; Koh, Yvette W. H.; Morrice, Nick; Tumanov, Sergey; Thomason, Peter A.; Nielson, Matthew; Tweedy, Luke; Muinonen-Martin, Andrew J.; Kamphorst, Jurre J.; Mackay, Gillian M.; Insall, Robert H.;

ABSTRACT Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients. The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside. They then migra... View more
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