LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

Article, Preprint English OPEN
Susanto, Olivia ; Koh, Yvette W. H. ; Morrice, Nick ; Tumanov, Sergey ; Thomason, Peter A. ; Nielson, Matthew ; Tweedy, Luke ; Muinonen-Martin, Andrew J. ; Kamphorst, Jurre J. ; Mackay, Gillian M. ; Insall, Robert H. (2017)
  • Publisher: The Company of Biologists Ltd
  • Journal: Journal of Cell Science, volume 130, issue 20, pages 3,455-3,466 (issn: 0021-9533, eissn: 1477-9137)
  • Related identifiers: pmc: PMC5665449, doi: 10.1242/jcs.207514, doi: 10.1101/153510
  • Subject: Research Article | Metastasis | LPP3 | Melanoma | Self-generated gradients | LPA | Chemotaxis
    mesheuropmc: biological phenomena, cell phenomena, and immunity | lipids (amino acids, peptides, and proteins)

ABSTRACT Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients. The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside. They then migra... View more
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